PMID- 23537298
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20130329
IS  - 1532-4230 (Electronic)
IS  - 1532-1819 (Linking)
VI  - 34
IP  - 2
DP  - 2013
TI  - Study of association between HLA-DR4 and DR53 and autoantibody detection in 
      rheumatoid arthritis.
PG  - 126-33
LID - 10.1080/15321819.2012.690357 [doi]
AB  - The present study explored the association between human leukocyte antigen 
      (HLA)-DR4, DR53, and auto antibodies in rheumatoid arthritis (RA) and its 
      clinical significance. A total of 305 patients with RA and 50 healthy subjects 
      who underwent medical examination were evaluated. HLA-DR4 and HLA-DR53 and auto 
      antibodies were detected. The results showed that frequencies of HLA-DR4 and 
      HLA-DR53 alleles in RA patients were 42.95% and 54.75%, respectively, which were 
      significantly different from those in control group (p < 0.01). Frequencies of 
      anti-cyclic citrullinated peptide antibody (CCP), anti-RA33, anti-keratin 
      antibody (AKA), and anti-nuclear antibody (ANA) in RA patients (n = 305) were 
      72.13%, 36.39%, 44.92%, and 60.98%, respectively. Results of rheumatoid factor 
      (RF) and C-reactive protein (CRP) were 148.29 +/- 391.01 IU/mL and 18.14 +/- 26.87 
      mg/L, respectively, which were significantly different from those in control 
      group (p < 0.01, t-test). The results indicated that the HLA- DR4 gene was 
      clearly associated with susceptibility of RA. Combined detection of related auto 
      antibodies might improve diagnosis rate of RA significantly, and the positive 
      rate was higher than that for a single antibody.
FAU - Zhou, Yongmei
AU  - Zhou Y
AD  - Laboratory Center of Medical College, Nanchang University, Nanching, P R China.
FAU - Tan, Liming
AU  - Tan L
FAU - Que, Qiuhua
AU  - Que Q
FAU - Li, Hua
AU  - Li H
FAU - Cai, Lili
AU  - Cai L
FAU - Cao, Liping
AU  - Cao L
FAU - Ye, Qian
AU  - Ye Q
FAU - Xiong, Jinwang
AU  - Xiong J
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Immunoassay Immunochem
JT  - Journal of immunoassay & immunochemistry
JID - 100963688
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DR53)
RN  - 0 (HLA-DRB4 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/blood/diagnosis/*genetics/immunology
MH  - Autoantibodies/blood/*genetics/immunology
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/blood/*genetics/immunology
MH  - HLA-DR4 Antigen/blood/*genetics/immunology
MH  - HLA-DRB4 Chains/blood/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides, Cyclic/blood
MH  - Rheumatoid Factor/blood
EDAT- 2013/03/30 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/03/30 06:00
PHST- 2013/03/30 06:00 [entrez]
PHST- 2013/03/30 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - 10.1080/15321819.2012.690357 [doi]
PST - ppublish
SO  - J Immunoassay Immunochem. 2013;34(2):126-33. doi: 10.1080/15321819.2012.690357.