PMID- 2353793
OWN - NLM
STAT- MEDLINE
DCOM- 19900716
LR  - 20061115
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 27
IP  - 4
DP  - 1990 Apr
TI  - A long-term prospective study of optic neuritis: evaluation of risk factors.
PG  - 386-93
AB  - Eighty-six patients with monosymptomatic optic neuritis of unknown cause were 
      followed prospectively for a median period of 12.9 years. At onset, cerebrospinal 
      fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal 
      immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen 
      (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) 
      was established in 33 patients. Actuarial analysis showed that the cumulative 
      probability of developing MS within 15 years was 45%. Three risk factors were 
      identified: low age and abnormal CSF at onset, and early recurrence of optic 
      neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 
      antigen increased the risk for MS, but not significantly. Magnetic resonance 
      imaging detected bilateral discrete white matter lesions, similar to those in MS, 
      in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. 
      Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 
      with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred 
      better prognosis but did not preclude the development of MS.
FAU - Sandberg-Wollheim, M
AU  - Sandberg-Wollheim M
AD  - Department of Neurology, University Hospital, Lund, Sweden.
FAU - Bynke, H
AU  - Bynke H
FAU - Cronqvist, S
AU  - Cronqvist S
FAU - Holtas, S
AU  - Holtas S
FAU - Platz, P
AU  - Platz P
FAU - Ryder, L P
AU  - Ryder LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/cerebrospinal fluid/complications/*diagnosis
MH  - Optic Neuritis/cerebrospinal fluid/*epidemiology/etiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Factors
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.1002/ana.410270406 [doi]
PST - ppublish
SO  - Ann Neurol. 1990 Apr;27(4):386-93. doi: 10.1002/ana.410270406.