PMID- 23539500
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1479-6708 (Print)
IS  - 1748-6971 (Electronic)
IS  - 1479-6708 (Linking)
VI  - 7
IP  - 3
DP  - 2012 May 1
TI  - Persistent region-dependent neuroinflammation, NMDA receptor loss and atrophy in 
      an animal model of penetrating brain injury.
PG  - 329-339
AB  - Dynamic changes in neuroinflammation and glutamate NMDA receptors (NMDAR) have 
      been noted in traumatic and ischemic brain injury. AIM: Here we investigate the 
      time course and regional distribution of these changes and their relationship 
      with atrophy in a rat model of penetrating brain injury. MATERIALS METHODS: 
      Quantitative autoradiography, with the neuroinflammation marker [(3)H]PK11195 and 
      the NMDAR antagonist [(125)I]iodoMK801, was performed on brains of animals 
      subjected to a unilateral wireknife injury at the level of striatum and killed 3 
      - 60 days later. Regional atrophy was measured by morphometry. RESULTS: The 
      injury produced large increases in [(3)H]PK11195 binding density in cortical and 
      septal regions adjacent to the knife track by day 7, with modest increases in the 
      striatum. [(125)I]iodoMK801 binding was reduced in cor tical and hippocampal 
      regions showing marked neuroinflammation, which showed marked atrophy at 
      subsequent time points. CONCLUSION: These results indicate that neuroinflammaton 
      and loss of NMDAR precede and predict tissue atrophy in cortical and hippocampal 
      regions.
FAU - Grossman, Rachel
AU  - Grossman R
AD  - Neurosurgery Department, Chaim Sheba Medical Center, Tel Hashomer, Israel.
FAU - Paden, Charles M
AU  - Paden CM
FAU - Fry, Pamela A
AU  - Fry PA
FAU - Rhodes, Ryon Sun
AU  - Rhodes RS
FAU - Biegon, Anat
AU  - Biegon A
LA  - eng
GR  - R01 NS050285/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Future Neurol
JT  - Future neurology
JID - 101278119
PMC - PMC3607550
MID - NIHMS384445
OTO - NOTNLM
OT  - NMDA receptors
OT  - TSPO
OT  - brain atrophy
OT  - brain injury
OT  - neuroinflammation
OT  - peripheral benzodiazepine receptors
EDAT- 2013/03/30 06:00
MHDA- 2013/03/30 06:01
PMCR- 2013/03/25
CRDT- 2013/03/30 06:00
PHST- 2013/03/30 06:00 [entrez]
PHST- 2013/03/30 06:00 [pubmed]
PHST- 2013/03/30 06:01 [medline]
PHST- 2013/03/25 00:00 [pmc-release]
AID - 10.2217/fnl.12.25 [doi]
PST - ppublish
SO  - Future Neurol. 2012 May 1;7(3):329-339. doi: 10.2217/fnl.12.25.