PMID- 23540412
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20130401
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 35
IP  - 4
DP  - 2013 May
TI  - ACE and ADD1 gene in extra and intracranial atherosclerosis in ischaemic stroke.
PG  - 429-34
LID - 10.1179/1743132813Y.0000000161 [doi]
AB  - OBJECTIVE: Hypertension is closely linked to ischaemic stroke (IS) and 
      atherosclerosis, but there are no studies correlating the candidate hypertensive 
      gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with 
      magnetic resonance angiographic (MRA) abnormality, therefore this study was 
      undertaken. METHODS: Patients with magnetic resonance imaging (MRI) proven IS 
      were included and their demography, stroke risk factors, and clinical findings 
      were noted. Both intracranial (IC) and extracranial (EC) MRA were performed and 
      more than 50% stenosis was considered significant. Angiotensin converting enzyme 
      and ADD1 gene polymorphism was evaluated by polymerase chain reaction (PCR) both 
      in patients and 188 controls. RESULTS: Angiotensin converting enzyme and ADD1 
      polymorphism were performed in 151 patients whose median age was 60 years and 
      26.5% were females. Magnetic resonance angiography was abnormal in 77.5%; 
      extracranial magnetic resonance angiography (ECMRA) in 58.3%, and intracranial 
      magnetic resonance angiography (ICMRA) in 66.7%. The conventional risk factors 
      were not different between the IS patients with and without MRA abnormalities. 
      The presence of DD genotype (OR 3.86, 95% CI 0.78-2.28, P = 0.0001) and ADD1 GW 
      genotype (OR 2.05, 95% CI 1.28-3.27, P = 0.003) significantly increased the risk 
      of IS compared to controls. Both genotype and allele frequency of ACE and ADD1 
      were higher in MRA abnormal IS patients compared to controls; however, these were 
      not significantly different between the patients with and without MRA 
      abnormality. CONCLUSION: In IS patients, DD genotype and D allele of ACE gene and 
      W allele of ADD1 gene were significantly related to MRA abnormality compared to 
      controls but there was no association of ACE and ADD1 gene polymorphism in IS 
      patients with MRA and without abnormality.
FAU - Kalita, Jayantee
AU  - Kalita J
AD  - Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Misra, Usha K
AU  - Misra UK
FAU - Kumar, Bishwanath
AU  - Kumar B
FAU - Somarajan, Bindu I
AU  - Somarajan BI
FAU - Kumar, Sunil
AU  - Kumar S
FAU - Mittal, Balraj
AU  - Mittal B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Intracranial Arteriosclerosis/*genetics
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Polymorphism, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sterol Regulatory Element Binding Protein 1/*genetics
MH  - Stroke/*genetics
MH  - Young Adult
EDAT- 2013/04/02 06:00
MHDA- 2013/09/24 06:00
CRDT- 2013/04/02 06:00
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 10.1179/1743132813Y.0000000161 [doi]
PST - ppublish
SO  - Neurol Res. 2013 May;35(4):429-34. doi: 10.1179/1743132813Y.0000000161.