PMID- 23540941
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20161125
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 34
IP  - 8
DP  - 2013 Aug
TI  - Measurements of medial temporal lobe atrophy for prediction of Alzheimer's 
      disease in subjects with mild cognitive impairment.
PG  - 2003-13
LID - S0197-4580(13)00064-X [pii]
LID - 10.1016/j.neurobiolaging.2013.02.002 [doi]
AB  - Our aim was to compare the predictive accuracy of 4 different medial temporal 
      lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive 
      impairment (MCI). Manual hippocampal measurement, automated atlas-based 
      hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle 
      measurement were compared. Predictive accuracy for AD 2 years after baseline was 
      assessed by receiver operating characteristics analyses with area under the curve 
      as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years 
      after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were 
      investigated. Subjects with MCI were selected from the Development of Screening 
      Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study 
      (n = 156) and the single-center VU medical center (n = 172). At follow-up, area 
      under the curve was highest for automated atlas-based hippocampal measurement 
      (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) 
      and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal 
      measurements correlated with CSF total tau and phosphorylated tau, not with 
      beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF 
      beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are 
      the best predictors of AD conversion in subjects with MCI.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Clerx, Lies
AU  - Clerx L
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for 
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the 
      Netherlands. L.Clerx@maastrichtuniversity.nl
FAU - van Rossum, Ineke A
AU  - van Rossum IA
FAU - Burns, Leah
AU  - Burns L
FAU - Knol, Dirk L
AU  - Knol DL
FAU - Scheltens, Philip
AU  - Scheltens P
FAU - Verhey, Frans
AU  - Verhey F
FAU - Aalten, Pauline
AU  - Aalten P
FAU - Lapuerta, Pablo
AU  - Lapuerta P
FAU - van de Pol, Laura
AU  - van de Pol L
FAU - van Schijndel, Ronald
AU  - van Schijndel R
FAU - de Jong, Remko
AU  - de Jong R
FAU - Barkhof, Frederik
AU  - Barkhof F
FAU - Wolz, Robin
AU  - Wolz R
FAU - Rueckert, Daniel
AU  - Rueckert D
FAU - Bocchetta, Martina
AU  - Bocchetta M
FAU - Tsolaki, Magdalini
AU  - Tsolaki M
FAU - Nobili, Flavio
AU  - Nobili F
FAU - Wahlund, Lars-Olaf
AU  - Wahlund LO
FAU - Minthon, Lennart
AU  - Minthon L
FAU - Frolich, Lutz
AU  - Frolich L
FAU - Hampel, Harald
AU  - Hampel H
FAU - Soininen, Hilkka
AU  - Soininen H
FAU - Visser, Pieter Jelle
AU  - Visser PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130327
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*diagnosis/etiology/*pathology/psychology
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Atrophy
MH  - Biomarkers/cerebrospinal fluid
MH  - Cognition
MH  - Cognitive Dysfunction/complications/*diagnosis/*pathology/psychology
MH  - Disease Progression
MH  - Female
MH  - Forecasting
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Peptide Fragments/cerebrospinal fluid
MH  - tau Proteins/cerebrospinal fluid
EDAT- 2013/04/02 06:00
MHDA- 2013/11/05 06:00
CRDT- 2013/04/02 06:00
PHST- 2013/01/24 00:00 [received]
PHST- 2013/02/09 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - S0197-4580(13)00064-X [pii]
AID - 10.1016/j.neurobiolaging.2013.02.002 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2013 Aug;34(8):2003-13. doi: 
      10.1016/j.neurobiolaging.2013.02.002. Epub 2013 Mar 27.