PMID- 23541493
OWN - NLM
STAT- MEDLINE
DCOM- 20131226
LR  - 20210223
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 106
DP  - 2013 May
TI  - Chronic co-administration of the cannabinoid receptor agonist WIN55,212-2 during 
      puberty or adulthood reverses 3,4 methylenedioxymetamphetamine (MDMA)-induced 
      deficits in recognition memory but not in effort-based decision making.
PG  - 91-100
LID - S0091-3057(13)00077-4 [pii]
LID - 10.1016/j.pbb.2013.03.011 [doi]
AB  - Cannabis and 3,4 methylenedioxymetamphetamine (MDMA, "ecstasy") are the most 
      frequently combined illegal drugs among young adults in western societies. This 
      study examined the effects of chronic co-administration of the cannabinoid 
      receptor agonist WIN55,212-2 (WIN) and MDMA on working memory and effort-based 
      decision making in rats. Treatment consisted of MDMA (7.5 mg/kg), WIN (1.2 
      mg/kg), a combination of these substances (MDMA+WIN) or vehicle over a period of 
      25 days during puberty (PD40-65) or adulthood (PD80-105). Ten days after the last 
      treatment, WIN reversed MDMA-induced working memory deficits in the object 
      recognition test in animals treated during adulthood or puberty, but had no 
      influence on impairment of adult rats in the effort-based T-maze task. No 
      differences were observed between groups of pubertally treated rats in the 
      decision making task. During a subsequent acute drug challenge MDMA and MDMA+WIN 
      decreased high reward choices in both age groups, indicating MDMA-induced 
      cost-aversive choice. Differential long-term interactions on the neuronal level 
      in the hippocampus and MDMA-induced disturbances in cortico-limbic connections 
      are suggested.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Schulz, Sybille
AU  - Schulz S
AD  - Brain Research Institute, Department of Neuropharmacology, University of Bremen, 
      28359 Bremen, Germany. s.schulz@uni-bremen.de
FAU - Becker, Thorsten
AU  - Becker T
FAU - Nagel, Ulrich
AU  - Nagel U
FAU - von Ameln-Mayerhofer, Andreas
AU  - von Ameln-Mayerhofer A
FAU - Koch, Michael
AU  - Koch M
LA  - eng
PT  - Journal Article
DEP - 20130327
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Benzoxazines)
RN  - 0 (Morpholines)
RN  - 0 (Naphthalenes)
RN  - 5H31GI9502 
      ((3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Benzoxazines/*administration & dosage/pharmacology
MH  - Decision Making/*drug effects
MH  - Male
MH  - Maze Learning
MH  - Memory/*drug effects
MH  - Morpholines/*administration & dosage/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Naphthalenes/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Sexual Maturation
EDAT- 2013/04/02 06:00
MHDA- 2013/12/27 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/11/02 00:00 [received]
PHST- 2013/03/15 00:00 [revised]
PHST- 2013/03/19 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/12/27 06:00 [medline]
AID - S0091-3057(13)00077-4 [pii]
AID - 10.1016/j.pbb.2013.03.011 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2013 May;106:91-100. doi: 10.1016/j.pbb.2013.03.011. 
      Epub 2013 Mar 27.