PMID- 23541842
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 150
IP  - 2
DP  - 2013 Sep 5
TI  - Childhood emotional environment and self-injurious behaviors: the moderating role 
      of the BDNF Val66Met polymorphism.
PG  - 594-600
LID - S0165-0327(13)00175-4 [pii]
LID - 10.1016/j.jad.2013.01.050 [doi]
AB  - BACKGROUND: Previous theory has suggested that invalidating environments in the 
      form of emotional maltreatment should be a specific risk factor for the 
      development of self-injurious behaviors (Linehan, 1993, Cognitive-Behavioral 
      Treatment of Borderline Personality Disorder, New York, Guilford Press). However, 
      results from previous studies have been mixed, possibly indicating that this 
      effect may not be the same for all individuals. In fact, some individuals may be 
      more susceptible to environmental influences (i.e., phenotypic plasticity), and 
      this susceptibility may be in part a function of genes that are involved in 
      neuroplasticity (e.g., the brain-derived neurotrophic factor [BDNF] Val66Met 
      polymorphism). METHOD: We explored the interaction between retrospective reports 
      of childhood emotional environment and the BDNF Val66Met polymorphism in relation 
      to a history of two main types of self-injurious behaviors, suicide attempt and 
      nonsuicidal self-injury (NSSI), in a sample of individuals with a history of 
      involvement in the criminal justice system. RESULTS: For individuals with two Val 
      alleles, there was a significant direct relationship between emotional 
      maltreatment and self-injurious behaviors. However, the relationship was not 
      significant for Met carriers. LIMITATIONS: The data are cross-sectional, which 
      means causal inferences cannot be drawn. CONCLUSIONS: The results indicate the 
      possibility of a common etiological pathway for NSSI and suicide attempts.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Bresin, Konrad
AU  - Bresin K
AD  - Department of Psychology, University of Illinois Urbana-Champaign, 603 East 
      Daniel Street, Champaign, IL 61820, United States. Konrad.Bresin@gmail.com
FAU - Sima Finy, M
AU  - Sima Finy M
FAU - Verona, Edelyn
AU  - Verona E
LA  - eng
PT  - Journal Article
DEP - 20130329
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child Abuse/*psychology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
MH  - Self-Injurious Behavior/*genetics
MH  - *Suicide, Attempted
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Invalidating environment
OT  - Self-injury
OT  - Suicide
OT  - Val66Met
EDAT- 2013/04/02 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - S0165-0327(13)00175-4 [pii]
AID - 10.1016/j.jad.2013.01.050 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Sep 5;150(2):594-600. doi: 10.1016/j.jad.2013.01.050. Epub 
      2013 Mar 29.