PMID- 23541976
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20211203
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 62
IP  - 2
DP  - 2013 May
TI  - Association between interleukin 10 gene -1082 A/G polymorphism and the risk of 
      type 2 diabetes mellitus: a meta-analysis of 4250 subjects.
PG  - 226-31
LID - S1043-4666(13)00097-5 [pii]
LID - 10.1016/j.cyto.2013.02.025 [doi]
AB  - Increasing evidence suggests that interleukin 10 (IL 10) gene -1082 A/G 
      (rsl800896) polymorphism may be associated with an increased risk of type 2 
      diabetes mellitus (T2DM). However, the results are inconsistent. The aim of this 
      study is to analyze the association between this variant and the T2DM risk by 
      meta-analysis. PubMed, Embase, Web of Science, and Google Scholar were searched 
      from January 1, 1989 to February 17, 2012, as well as hand searching of the 
      references of identified articles were performed. All the statistical tests were 
      performed using Stata 11.0. Seven case-control studies were identified, covering 
      a total of 1879 T2DM cases and 2371 controls. The results showed evidence of 
      significant association between IL 10 gene -1082 A/G polymorphism and T2DM risk 
      (for G/G+G/A vs. A/A: OR=1.21, 95% CI=1.05-1.40, p=0.010, p=0.040 after 
      Bonferroni testing). In the subgroup analysis by ethnicity, no significant 
      association was found between IL 10 gene -1082 A/G polymorphism and T2DM risk in 
      Europeans. In summary, results from this meta-analysis provide evidence that IL 
      10 gene -1082 G allele is associated with increased risk of T2DM.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Yin, Yan-Wei
AU  - Yin YW
AD  - Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, 
      Haidian District, Beijing 100142, China. shuaishuaijita@sohu.com
FAU - Hu, Ai-Min
AU  - Hu AM
FAU - Sun, Qian-Qian
AU  - Sun QQ
FAU - Zhang, Bei-Bei
AU  - Zhang BB
FAU - Liu, Hong-Li
AU  - Liu HL
FAU - Wang, Qi
AU  - Wang Q
FAU - Zeng, Yi-Hua
AU  - Zeng YH
FAU - Xu, Rui-Jia
AU  - Xu RJ
FAU - Zhang, Shi-Jie
AU  - Zhang SJ
FAU - Shi, Long-Bao
AU  - Shi LB
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130329
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Ethnicity/genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2013/04/02 06:00
MHDA- 2014/01/30 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2013/01/30 00:00 [revised]
PHST- 2013/02/21 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
AID - S1043-4666(13)00097-5 [pii]
AID - 10.1016/j.cyto.2013.02.025 [doi]
PST - ppublish
SO  - Cytokine. 2013 May;62(2):226-31. doi: 10.1016/j.cyto.2013.02.025. Epub 2013 Mar 
      29.