PMID- 23542005
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20211021
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 31
IP  - 6
DP  - 2013 Oct
TI  - Alcohol exposure during development: Impact on the epigenome.
PG  - 391-7
LID - S0736-5748(13)00046-4 [pii]
LID - 10.1016/j.ijdevneu.2013.03.010 [doi]
AB  - Fetal alcohol spectrum disorders represent a wide range of symptoms associated 
      with in utero alcohol exposure. Animal models of FASD have been useful in 
      determining the specific neurological consequences of developmental alcohol 
      exposure, but the mechanisms of those consequences are unclear. Long-lasting 
      changes to the epigenome are proposed as a mechanism of alcohol-induced 
      teratogenesis in the hippocampus. The current study utilized a three-trimester 
      rodent model of FASD to examine changes to some of the enzymatic regulators of 
      the epigenome in adolescence. Combined pre- and post-natal alcohol 
      exposureresulted in a significant increase in DNA methyltransferase activity 
      (DNMT), without affecting histone deacetylase activity (HDAC). Developmental 
      alcohol exposure also caused a change in gene expression of regulators of the 
      epigenome, in particular, DNMT1, DNMT3a, and methyl CpG binding protein 2 
      (MeCP2). The modifications of the activity and expression of epigenetic 
      regulators in the hippocampus of rodents perinatally exposed to alcohol suggest 
      that alcohol's impact on the epigenome and its regulators may be one of the 
      underlying mechanisms of alcohol teratogenesis.
CI  - Copyright (c) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Perkins, Amy
AU  - Perkins A
AD  - Department of Psychology, University of South Carolina, Columbia, SC, 29208, 
      United States. fincha@sc.edu
FAU - Lehmann, Claudia
AU  - Lehmann C
FAU - Lawrence, R Charles
AU  - Lawrence RC
FAU - Kelly, Sandra J
AU  - Kelly SJ
LA  - eng
GR  - R01 AA011566/AA/NIAAA NIH HHS/United States
GR  - R01AA011566/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130327
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Central Nervous System Depressants/*adverse effects/blood
MH  - DNA (Cytosine-5-)-Methyltransferases/metabolism
MH  - Disease Models, Animal
MH  - Epigenesis, Genetic/*drug effects
MH  - Ethanol/*adverse effects/blood
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/etiology/*physiopathology
MH  - Histone Deacetylases/metabolism
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Rats, Long-Evans
PMC - PMC3703477
MID - NIHMS461281
OTO - NOTNLM
OT  - ARND
OT  - BAC
OT  - BDNF
OT  - CNS
OT  - CT
OT  - DMR
OT  - DNA methyltransferase
OT  - DNMT
OT  - ET
OT  - Epigenetics
OT  - FAS
OT  - FASD
OT  - Fetal alcohol spectrum disorders
OT  - GD
OT  - HAT
OT  - HDAC
OT  - Hippocampus
OT  - IC
OT  - MBDs
OT  - MeCP2
OT  - NC
OT  - PD
OT  - PFC
OT  - alcohol-related neurodevelopmental disorder
OT  - blood alcohol concentration
OT  - brain-derived neurotrophic factor
OT  - central nervous system
OT  - crossing threshold
OT  - differentially methylated region
OT  - ethanol-exposed group
OT  - fetal alcohol spectrum disorder
OT  - fetal alcohol syndrome
OT  - gestational day
OT  - histone acetyltransferase
OT  - histone deacetylase
OT  - intubated control group
OT  - methyl CpG binding protein 2
OT  - methyl binding domains
OT  - non-treated control group
OT  - postnatal day
OT  - prefrontal cortex
EDAT- 2013/04/02 06:00
MHDA- 2014/02/15 06:00
PMCR- 2014/10/01
CRDT- 2013/04/02 06:00
PHST- 2012/08/31 00:00 [received]
PHST- 2013/03/15 00:00 [revised]
PHST- 2013/03/16 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - S0736-5748(13)00046-4 [pii]
AID - 10.1016/j.ijdevneu.2013.03.010 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2013 Oct;31(6):391-7. doi: 10.1016/j.ijdevneu.2013.03.010. 
      Epub 2013 Mar 27.