PMID- 23542057
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20130527
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 7
DP  - 2013 Jul
TI  - Lesion HLA-F expression is irrelevant to prognosis for patients with gastric 
      cancer.
PG  - 828-32
LID - S0198-8859(13)00073-6 [pii]
LID - 10.1016/j.humimm.2013.03.002 [doi]
AB  - Alteration of human leukocyte antigen (HLA) antigen expression has been supposed 
      to play critical roles in progression of malignancies. However, clinical 
      significance of the non-classical HLA class I antigen HLA-F remains largely 
      unknown. In this study, HLA-F expression in 277 primary gastric cancer (GC) 
      lesions was analyzed by immunohistochemistry. Data revealed that HLA-F expression 
      was observed in 71.1% (197/277) of the GC lesions. Lesion HLA-F expression was 
      unrelated to the clinicoparameters such as gender, age, depth of tumor invasion 
      and disease stage. Survival analysis revealed that HLA-F expression in GC lesion 
      was unrelated to patient prognosis (p=0.190). The mean overall survival time 
      (MOS) for lesion HLA-F negative and positive patients was 11.3 months (95% CI: 
      9.3-13.3) and 13.9 months (95% CI: 10.5-17.3), respectively. In conclusion, our 
      study provided the evidence that HLA-F expression was unrelated to prognosis for 
      patients with gastric cancer.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Jian-Gang
AU  - Zhang JG
AD  - Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      College, Linhai, Zhejiang, China.
FAU - Zhang, Xia
AU  - Zhang X
FAU - Lin, Aifen
AU  - Lin A
FAU - Yan, Wei-Hua
AU  - Yan WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130327
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-F antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Expression Regulation, Neoplastic/genetics/immunology
MH  - Genetic Association Studies
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Stomach Neoplasms/*immunology/mortality
MH  - Survival Analysis
EDAT- 2013/04/02 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2012/11/13 00:00 [revised]
PHST- 2013/03/19 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0198-8859(13)00073-6 [pii]
AID - 10.1016/j.humimm.2013.03.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Jul;74(7):828-32. doi: 10.1016/j.humimm.2013.03.002. Epub 2013 
      Mar 27.