PMID- 23542873
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 7
IP  - 2
DP  - 2013 Feb
TI  - The HLA Class II Associations with Rheumatic Heart Disease in South Indian 
      Patients: A Preliminary Study.
PG  - 302-4
LID - 10.7860/JCDR/2013/4509.2752 [doi]
AB  - INTRODUCTION: Rheumatic heart disease (RHD) occurs in 30-45% of the patients with 
      rheumatic fever (RF) and it leads to chronic valvular lesions. The human 
      leukocyte antigen (HLA) might confer a susceptibility to RHD. The aim of the 
      present study was to determine the prevalent HLA class II DR/DQ allelic types 
      which were associated with rheumatic heart disease (RHD) in a small group of 
      south Indian patients and to compare them with those in the control subjects. 
      METHODS: A total of 23 patients who were diagnosed with RHD and 6 control samples 
      were included in this study. A low resolution HLA Class II DR/DQ typing was 
      performed on the blood samples by the PCR-SSP method. RESULTS AND CONCLUSION: The 
      DRB3*01:01:02:01 allele showed a positive association with RHD, whereas the DQB1 
      loci alleles did not show any significant association.
FAU - Bajoria, Divya
AU  - Bajoria D
AD  - PhD Research Scholar, Department of Microbiology, Dr.A.L.Mudaliar Post Graduate 
      Institute of Basic Medical Sciences, University of Madras , Taramani, 
      Chennai-600113, India .
FAU - Menon, Thangam
AU  - Menon T
LA  - eng
PT  - Journal Article
DEP - 20130201
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3592297
OTO - NOTNLM
OT  - HLA Class II DR/DQ typing
OT  - Rheumatic Heart Disease
OT  - South India
EDAT- 2013/04/02 06:00
MHDA- 2013/04/02 06:01
PMCR- 2013/04/01
CRDT- 2013/04/02 06:00
PHST- 2012/05/09 00:00 [received]
PHST- 2012/11/24 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/04/02 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2013/4509.2752 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2013 Feb;7(2):302-4. doi: 10.7860/JCDR/2013/4509.2752. Epub 
      2013 Feb 1.