PMID- 23543129
OWN - NLM
STAT- MEDLINE
DCOM- 20140210
LR  - 20211021
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 102
IP  - 7
DP  - 2013 Jul
TI  - One-year outcome after CRT implantation in NYHA class IV in comparison to NYHA 
      class III patients.
PG  - 505-11
LID - 10.1007/s00392-013-0558-1 [doi]
AB  - BACKGROUND: The aim of the analysis was to compare the outcome of heart failure 
      patients in New York Heart Association (NYHA) class IV to that of NYHA class III 
      patients 1 year after implantation of a CRT device. METHODS: The analysis was 
      based on the 405 CRT patients enrolled in the MASCOT trial. At enrollment, 350 
      patients (86%) were in NYHA class III and 55 (14 %) were in NYHA class IV. 
      RESULTS: At 1-year follow-up, the improvement of the ejection fraction was not 
      statistically significantly different between NYHA class III (+7.6 +/- 11.7%) and 
      NYHA class IV patients (+9.2 +/- 14.2 %; p = 0.78). NYHA class IV patients had a 
      better mean NYHA class reduction with -1.93 +/- 0.83 than NYHA class III patients 
      with -0.93 +/- 0.70 (p < 0.0001). There was a greater mean quality of life 
      improvement in NYHA class IV (-27.2 +/- 20.9) compared to NYHA class III (-17.7 +/- 
      23.9; p = 0.02). All-cause mortality as well as cardiac mortality remained higher 
      in NYHA class IV with 25.5 and 16.4% than in NYHA class III with 7.1 and 3.1% (p 
      < 0.0001). CONCLUSIONS: In this study, 14% of all patients receiving a CRT device 
      had NYHA class IV at implantation. The data support the concept to implant a CRT 
      device in NYHA class IV patients, because at 1 year after implantation, they 
      experienced better symptomatic improvement compared to NYHA class III patients. 
      The higher cardiac as well as non-cardiac mortality resulted in a fivefold higher 
      all-cause mortality compared to NYHA class III patients.
FAU - Schuchert, Andreas
AU  - Schuchert A
AD  - Friedrich-Ebert Hospital, Medical Clinic, Friesenstr. 11, 24531 Neumunster, 
      Germany. andreas.schuchert@fek.de
FAU - Muto, Carmine
AU  - Muto C
FAU - Maounis, Themistoklis
AU  - Maounis T
FAU - Frank, Robert
AU  - Frank R
FAU - Ella, Rita Omega
AU  - Ella RO
FAU - Polauck, Alexander
AU  - Polauck A
FAU - Padeletti, Luigi
AU  - Padeletti L
CN  - Mascot Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130331
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Aged
MH  - Cardiac Resynchronization Therapy/*methods
MH  - *Cardiac Resynchronization Therapy Devices
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/classification/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Single-Blind Method
MH  - Treatment Outcome
FIR - Acquati, Fiorenzo
IR  - Acquati F
FIR - Alessandrini, Francesco
IR  - Alessandrini F
FIR - Bongiorni, Maria-Grazia
IR  - Bongiorni MG
FIR - Brachmann, Johannes
IR  - Brachmann J
FIR - Calvi, Valeria
IR  - Calvi V
FIR - Chan, Ngai-yin
IR  - Chan NY
FIR - Dahl Christensen, Per
IR  - Dahl Christensen P
FIR - Fiorello, Pierre
IR  - Fiorello P
FIR - Flammang, Daniel
IR  - Flammang D
FIR - Foti, Francesco
IR  - Foti F
FIR - Frank, Robert
IR  - Frank R
FIR - Fusco, Antonio
IR  - Fusco A
FIR - Goode, Grahame
IR  - Goode G
FIR - Gras, Daniel
IR  - Gras D
FIR - Gruska, Michael
IR  - Gruska M
FIR - Jauvert, Gael
IR  - Jauvert G
FIR - Kachboura, Salem
IR  - Kachboura S
FIR - Kaltofen, Gert
IR  - Kaltofen G
FIR - Kiowski, Wolfgang
IR  - Kiowski W
FIR - Lisi, Francesco
IR  - Lisi F
FIR - Maounis, Themistoclis
IR  - Maounis T
FIR - Occhetta, Eraldo
IR  - Occhetta E
FIR - Padeletti, Luigi
IR  - Padeletti L
FIR - Piot, Olivier
IR  - Piot O
FIR - Poulard, Jean-Ernst
IR  - Poulard JE
FIR - Rey, Jean-Luc
IR  - Rey JL
FIR - Saoudi, Nadir
IR  - Saoudi N
FIR - Schuchert, Andreas
IR  - Schuchert A
FIR - Thomas, Olivier
IR  - Thomas O
FIR - Tuccillo, Bernardo
IR  - Tuccillo B
FIR - Vesterlund, Thomas
IR  - Vesterlund T
FIR - Vock, Paul
IR  - Vock P
FIR - Weide, Arnd
IR  - Weide A
FIR - Zecchi, Paolo
IR  - Zecchi P
EDAT- 2013/04/02 06:00
MHDA- 2014/02/11 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/11/09 00:00 [received]
PHST- 2013/03/18 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2014/02/11 06:00 [medline]
AID - 10.1007/s00392-013-0558-1 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2013 Jul;102(7):505-11. doi: 10.1007/s00392-013-0558-1. Epub 
      2013 Mar 31.