PMID- 23546472 OWN - NLM STAT- MEDLINE DCOM- 20140204 LR - 20190819 IS - 1347-4820 (Electronic) IS - 1346-9843 (Linking) VI - 77 IP - 7 DP - 2013 TI - Extent of late gadolinium enhancement on cardiovascular magnetic resonance imaging and its relation to left ventricular longitudinal functional reserve during exercise in patients with hypertrophic cardiomyopathy. PG - 1742-9 AB - BACKGROUND: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25 W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as DeltaE'xE'base and DeltaS'xS'base, where DeltaE' and DeltaS' are the changes in E' and S' from baseline to 50 W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as "percentage of LV mass containing LGE": %LV with LGE; range, 0-37%; median, 6%): group 1 (n=23), %LV with LGE <6%, and group 2, %LV with LGE >/=6%. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (DeltaE': 2.8+/-1.8 cm/s vs.1.5+/-1.0 cm/s, P=0.007; DeltaS': 2.2+/-1.2 cm/s vs. 0.9+/-0.8 cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (DeltaE'xE'(base): 12.8+/-7.7 vs. 5.5+/-3.4, P=0.001; DeltaS'xS'(base): 12.6+/-7.4 vs. 4.7+/-4.5, P<0.0001). CONCLUSIONS: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM. FAU - Moon, Jeonggeun AU - Moon J AD - Cardiology Division, Gachon University of Medicine and Science, Incheon, Korea. FAU - Hong, Yoo Jin AU - Hong YJ FAU - Kim, Young-Jin AU - Kim YJ FAU - Shim, Chi Young AU - Shim CY FAU - Jang, Yangsoo AU - Jang Y FAU - Chung, Namsik AU - Chung N FAU - Cho, Seung-Yun AU - Cho SY FAU - Ha, Jong-Won AU - Ha JW LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130402 PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - *Cardiomegaly/diagnostic imaging/physiopathology MH - Contrast Media/*administration & dosage MH - *Exercise MH - Female MH - Gadolinium/*administration & dosage MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Radiography MH - *Ventricular Function, Left EDAT- 2013/04/03 06:00 MHDA- 2014/02/05 06:00 CRDT- 2013/04/03 06:00 PHST- 2013/04/03 06:00 [entrez] PHST- 2013/04/03 06:00 [pubmed] PHST- 2014/02/05 06:00 [medline] AID - DN/JST.JSTAGE/circj/CJ-12-1378 [pii] AID - 10.1253/circj.cj-12-1378 [doi] PST - ppublish SO - Circ J. 2013;77(7):1742-9. doi: 10.1253/circj.cj-12-1378. Epub 2013 Apr 2.