PMID- 23546719
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20130402
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 992
DP  - 2013
TI  - Anti-factor Xa (anti-Xa) assay.
PG  - 265-72
LID - 10.1007/978-1-62703-339-8_19 [doi]
AB  - The anti-factor Xa (anti-Xa) assay is a functional assay that facilitates the 
      measurement of antithrombin (AT)-catalyzed inhibition of factor Xa by 
      unfractionated heparin (UFH) and direct inhibition of factor Xa by 
      low-molecular-weight heparin (LMWH) (Kitchen, Br J Haematol 111:397-406, 2000; 
      Walenga et al., Semin Thromb Hemost 11:17-25, 1985; Levine et al., Arch Intern 
      Med 154:49-56, 1994; Barrowcliffe et al., J Pharm Biomed Anal 7:217-226, 1989; 
      Triplett, Ther Drug Monit 1:173-197, 1979; Nelson, Clin Lab Sci 12:359-364, 1999; 
      Laffan and Manning, Dacie and Lewis: practical haematology, Churchill 
      Livingstone, London, pp 465-479, 2001; Olson et al., Arch Pathol Lab Med 
      122:782-798, 1998). Whilst automated methods for the determination of the 
      abilities of UFH and LMWH to inhibit factor Xa have been available since the 
      1970s, their cost was viewed to prohibit their broad use in the clinical 
      management of UFH and LMWH until relatively recently. The anti-Xa assay can also 
      be used to guide the determination of therapeutic APTT ranges in the clinical 
      management of UFH (Hirsh and Raschke, Chest 126:188S-203S, 2004). As a result, 
      the anti-Xa assay is commonly viewed as a heparin assay, despite the fact that it 
      actually provides a measure of UFH effect as opposed to a measure of UFH 
      concentration.
FAU - Newall, Fiona
AU  - Newall F
AD  - Department of Clinical Haematology, The Royal Children's Hospital, Melbourne, 
      Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antithrombin Proteins)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Antithrombin Proteins/analysis
MH  - Blood Coagulation
MH  - Blood Coagulation Tests/*methods
MH  - Factor Xa/*analysis
MH  - Heparin/*blood/metabolism
MH  - Heparin, Low-Molecular-Weight/*blood/metabolism
MH  - Humans
EDAT- 2013/04/03 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/04/03 06:00
PHST- 2013/04/03 06:00 [entrez]
PHST- 2013/04/03 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - 10.1007/978-1-62703-339-8_19 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2013;992:265-72. doi: 10.1007/978-1-62703-339-8_19.