PMID- 23547408
OWN - NLM
STAT- MEDLINE
DCOM- 20130508
LR  - 20161125
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 60
DP  - 2012 Sep
TI  - Carotid intima-media thickness in type 2 diabetes mellitus patients with cardiac 
      autonomic neuropathy.
PG  - 14-8
AB  - INTRODUCTION: Cardiac autonomic neuropathy (CAN) is an important complication of 
      type 2 diabetes mellitus (T2DM). Accelerated atherosclerosis is also common in 
      T2DM. Carotid intima media thickness (CIMT) is a surrogate marker of 
      atherosclerosis. We conducted a study to assess the CIMT in T2DM patients with 
      CAN. METHODS: In 84 T2DM patients cardiac autonomic function was assessed by five 
      clinical tests including: 1) heart rate variation during deep breathing, 2) hear 
      rate response to standing, 3) Valsalva ratio, 4) postural fall in systolic blood 
      pressure (BP) three minutes after standing, and 5) resting heart rate. CAN was 
      defined as two or more positive tests out of five for cardiac autonomic function. 
      CIMT was measured by two dimensional (2D) ultrasound. We also examined for 
      presence of any atherosclerotic plaque over intima of carotid artery as well as 
      within the carotid bulb. RESULTS: Thirty six (42.85 percent) out of 84 patients 
      were detected to have CAN. CAN was significantly associated with duration of 
      disease after its detection (P = 0.0253), high LDL cholesterol (P = 0.0418), low 
      HDL cholesterol (P = 0.0001), fasting blood sugar (FBS) level (P = 0.0012) and 
      CIMT (P = 0.0001) equal to or more than 69 mm. CONCLUSION: Increased CIMT equal 
      to or more than 69 mm is associated with high occurrence of CAN in diabetic 
      population. Duration of diabetes, abnormal lipid tests and FBS level 
      significantly influence the development of CAN.
FAU - Sinha, Pradip Kumar
AU  - Sinha PK
AD  - Dept. of Medicine, Medical College, 88 College Street, Kolkata-700073.
FAU - Santr, Gouranga
AU  - Santr G
FAU - De, Dibyendu
AU  - De D
FAU - Sah, Avishek
AU  - Sah A
FAU - Biswas, Kaushik
AU  - Biswas K
FAU - Bhattachary, Prithwiraj
AU  - Bhattachary P
FAU - Ghosh, Pramit
AU  - Ghosh P
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
RN  - 0 (Cholesterol, LDL)
SB  - IM
CIN - J Assoc Physicians India. 2012 Sep;60:9-10. PMID: 23547406
CIN - J Assoc Physicians India. 2013 Sep;61(9):681-2. PMID: 24772721
CIN - J Assoc Physicians India. 2013 Sep;61(9):682. PMID: 24772722
MH  - Adult
MH  - Aged
MH  - Autonomic Nervous System Diseases/*complications/diagnostic imaging
MH  - Blood Pressure/physiology
MH  - *Carotid Intima-Media Thickness
MH  - Cholesterol, LDL
MH  - Diabetes Mellitus, Type 2/*complications/diagnostic imaging
MH  - Diabetic Neuropathies/*physiopathology
MH  - Female
MH  - Heart Function Tests
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2013/04/04 06:00
MHDA- 2013/05/09 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/05/09 06:00 [medline]
PST - ppublish
SO  - J Assoc Physicians India. 2012 Sep;60:14-8.