PMID- 23547839
OWN - NLM
STAT- MEDLINE
DCOM- 20140813
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 55
IP  - 1
DP  - 2014 Jan
TI  - Prognostic factors and risk stratification in early mycosis fungoides.
PG  - 44-50
LID - 10.3109/10428194.2013.790541 [doi]
AB  - Available demographic, clinical, histologic, immunohistochemical and laboratory 
      findings, including serum cytokine/cytokine receptor levels, obtained at initial 
      evaluation in a cohort of 33 patients with mycosis fungoides (MF) at stages I-IIA 
      who had subsequent progression of disease were compared against 70 stage-matched 
      cases of MF without observed progression. Significant factors that correlated 
      with both disease progression and overall survival were: (1) presence of large 
      Pautrier microabscesses (10 or more atypical lymphocytes), (2) presence of 
      atypical lymphocytes with hyperchromatic or vesicular nuclei in the dermal 
      infiltrate, (3) less than 20% CD8 + cells in the dermal infiltrate and (4) above 
      normal (> 122 U/mL) serum immunoglobulin E (IgE) level. Combination of these 
      factors was used to construct prognostic groupings which, if validated, might be 
      useful to identify patients with clinically early MF at highest risk for disease 
      progression and poor outcome.
FAU - Vonderheid, Eric C
AU  - Vonderheid EC
AD  - Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center, Johns 
      Hopkins Medical Institutes , Baltimore, MD , USA.
FAU - Pavlov, Igor
AU  - Pavlov I
FAU - Delgado, Julio C
AU  - Delgado JC
FAU - Martins, Thomas B
AU  - Martins TB
FAU - Telang, Gladys H
AU  - Telang GH
FAU - Hess, Allan D
AU  - Hess AD
FAU - Kadin, Marshall E
AU  - Kadin ME
LA  - eng
PT  - Journal Article
DEP - 20130507
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Biomarkers)
RN  - 0 (Ki-1 Antigen)
SB  - IM
CIN - Leuk Lymphoma. 2014 Jan;55(1):7-8. PMID: 23725392
MH  - Biomarkers
MH  - Dermis/pathology
MH  - Disease Progression
MH  - Humans
MH  - Ki-1 Antigen/blood/metabolism
MH  - Lymphocytes/pathology
MH  - Mycosis Fungoides/metabolism/*mortality/*pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Skin Neoplasms/*mortality/*pathology
EDAT- 2013/04/04 06:00
MHDA- 2014/08/15 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
AID - 10.3109/10428194.2013.790541 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2014 Jan;55(1):44-50. doi: 10.3109/10428194.2013.790541. Epub 2013 
      May 7.