PMID- 23548124
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20220330
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 41
IP  - 2
DP  - 2013
TI  - Preventive and therapeutic effects of ginsenoside Rb1 for neural injury during 
      cerebral infarction in rats.
PG  - 341-52
LID - 10.1142/S0192415X13500250 [doi]
AB  - To examine the preventive and therapeutic effects of ginsenoside Rb1 for neural 
      injury during cerebral infarction, we used a middle cerebral artery occlusion 
      (MCAO) model in rats to investigate the effects of ginsenoside Rb1 with Edaravone 
      as a control. Ginsenoside Rb1 was given to the rats by intragastric 
      administration either before or after the MCAO surgery to study its preventive 
      and therapeutic effects. Ginsenoside Rb1-treated rats had a smaller infarct 
      volume than the positive control. Interleukin-1 (IL-1), brain-derived 
      neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF-alpha), neurofilament (NF) 
      and growth associated protein-43 (GAP-43) were measured to determine brain damage 
      and the recovery of nerves. These findings suggest that ginsenoside Rb1 has 
      neuroprotective effects in rats, and the protection efficiency is higher than 
      Edaravone. The protective mechanism is different from Edaravone. The preventive 
      ability of ginsenoside Rb1 is higher than its repair ability in neuroprotection 
      in vivo.
FAU - Jiang, Zhou
AU  - Jiang Z
AD  - Key Laboratory of Chronobiology, Ministry of Health (Sichuan University), Sichuan 
      University, Chengdu, Sichuan 610041, P. R. China.
FAU - Wang, Yuhui
AU  - Wang Y
FAU - Zhang, Xiaoyun
AU  - Zhang X
FAU - Peng, Tao
AU  - Peng T
FAU - Lu, Yun
AU  - Lu Y
FAU - Leng, Jianchun
AU  - Leng J
FAU - Xie, Quan
AU  - Xie Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ginsenosides)
RN  - 0 (Interleukin-1)
RN  - 0 (Neuroprotective Agents)
RN  - 7413S0WMH6 (ginsenoside Rb1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Infarction/*drug therapy/metabolism/prevention & control
MH  - Ginsenosides/*administration & dosage
MH  - Humans
MH  - Interleukin-1/metabolism
MH  - Male
MH  - Neurons/drug effects
MH  - Neuroprotective Agents/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2013/04/04 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - 10.1142/S0192415X13500250 [doi]
PST - ppublish
SO  - Am J Chin Med. 2013;41(2):341-52. doi: 10.1142/S0192415X13500250.