PMID- 23548318
OWN - NLM
STAT- MEDLINE
DCOM- 20140128
LR  - 20211021
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 61
IP  - 5
DP  - 2013 May
TI  - Is there a correlation between structural alterations and retinal sensitivity in 
      morphological patterns of diabetic macular edema?
PG  - 230-2
LID - 10.4103/0301-4738.97081 [doi]
AB  - Spectral domain optical coherence tomography (SDOCT) enables enhanced 
      visualization of retinal layers and delineation of structural alterations in 
      diabetic macular edema (DME). Microperimetry (MP) is a new technique that allows 
      fundus-related testing of local retinal sensitivity. Combination of these two 
      techniques would enable a structure-function correlation with insights into 
      pathomechanism of vision loss in DME. To correlate retinal structural derangement 
      with retinal sensitivity alterations in cases with diabetic macular edema, using 
      SDOCT and MP. Prospective study of 34 eyes of 30 patients with DME. All patients 
      underwent comprehensive ophthalmic examination, fluorescein angiography, 
      microperimetry and SDOCT. Four distinct morphological patterns of DME were 
      identified- diffuse retinal thickening (DRT), cystoid macular edema (CME), 
      schitic retinal thickening (SRT) and neurosensory detachment (NSD) of fovea. Some 
      retinal loci presented with a mixture of above patterns There was significant 
      difference in retinal thickness between groups (P<0.001). Focal retinal 
      sensitivity measurement revealed relatively preserved retinal sensitivity in 
      areas with DRT (13.8 dB), moderately reduced sensitivity (7.9 dB) in areas with 
      CME, and gross retinal sensitivity loss in areas with SRT (1.2 dB) and NSD (4.7 
      dB) (P<0.001). Analysis of regional scotoma depth demonstrated similar pattern. 
      Retinal sensitivity showed better correlation to OCT pattern (r=-0.68, P<0.001) 
      than retinal thickness (r=-0.44, P<0.001). Structure-function correlation allows 
      better understanding of the pathophysiology of visual loss in different 
      morphological types of DME. Classification of macular edema into these categories 
      has implications on the prognosis and predictive value of treatment.
FAU - Kothari, Abhishek R
AU  - Kothari AR
AD  - Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, 
      India.
FAU - Raman, Rajiv P G
AU  - Raman RP
FAU - Sharma, Tarun
AU  - Sharma T
FAU - Gupta, Muneesawar
AU  - Gupta M
FAU - Laxmi, G
AU  - Laxmi G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Diabetic Retinopathy/*diagnosis/physiopathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Macular Edema/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retina/pathology/*physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Visual Fields
PMC - PMC3730507
COIS- Conflict of Interest: None declared.
EDAT- 2013/04/04 06:00
MHDA- 2014/01/29 06:00
PMCR- 2013/05/01
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/01/29 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - 97081 [pii]
AID - IJO-61-230 [pii]
AID - 10.4103/0301-4738.97081 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2013 May;61(5):230-2. doi: 10.4103/0301-4738.97081.