PMID- 23548824
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20181202
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 187
IP  - 2
DP  - 2013 Jun 15
TI  - Bone marrow-derived mononuclear cells vs. mesenchymal stromal cells in 
      experimental allergic asthma.
PG  - 190-8
LID - S1569-9048(13)00093-1 [pii]
LID - 10.1016/j.resp.2013.03.014 [doi]
AB  - We compared the effects of bone marrow-derived mononuclear cells (BMMCs) and 
      mesenchymal stromal cells (MSCs) on airway inflammation and remodeling and lung 
      mechanics in experimental allergic asthma. C57BL/6 mice were sensitized and 
      challenged with ovalbumin (OVA group). A control group received saline using the 
      same protocol. Twenty-four hours after the last challenge, groups were further 
      randomized into subgroups to receive saline, BMMCs (2x10(6)) or MSCs (1x10(5)) 
      intratracheally. BMMC and MSC administration decreased cell infiltration, 
      bronchoconstriction index, alveolar collapse, collagen fiber content in the 
      alveolar septa, and interleukin (IL)-4, IL-13, transforming growth factor (TGF)-beta 
      and vascular endothelial growth factor (VEGF) levels compared to OVA-SAL. Lung 
      function, alveolar collapse, collagen fiber deposition in alveolar septa, and 
      levels of TGF-beta and VEGF improved more after BMMC than MSC therapy. In 
      conclusion, intratracheal BMMC and MSC administration effectively modulated 
      inflammation and fibrogenesis in an experimental model of asthma, but BMMCs was 
      associated with greater benefit in terms of reducing levels of 
      fibrogenesis-related growth factors.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Abreu, Soraia C
AU  - Abreu SC
AD  - Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of 
      Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Antunes, Mariana A
AU  - Antunes MA
FAU - de Castro, Julia C
AU  - de Castro JC
FAU - de Oliveira, Milena V
AU  - de Oliveira MV
FAU - Bandeira, Elga
AU  - Bandeira E
FAU - Ornellas, Debora S
AU  - Ornellas DS
FAU - Diaz, Bruno L
AU  - Diaz BL
FAU - Morales, Marcelo M
AU  - Morales MM
FAU - Xisto, Debora G
AU  - Xisto DG
FAU - Rocco, Patricia R M
AU  - Rocco PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130330
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Asthma/chemically induced/immunology/*pathology
MH  - Bone Marrow Cells/*pathology
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Lung/metabolism
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
EDAT- 2013/04/04 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/02/01 00:00 [received]
PHST- 2013/03/13 00:00 [revised]
PHST- 2013/03/25 00:00 [accepted]
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - S1569-9048(13)00093-1 [pii]
AID - 10.1016/j.resp.2013.03.014 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2013 Jun 15;187(2):190-8. doi: 
      10.1016/j.resp.2013.03.014. Epub 2013 Mar 30.