PMID- 23548825
OWN - NLM
STAT- MEDLINE
DCOM- 20141223
LR  - 20181203
IS  - 1421-9832 (Electronic)
IS  - 1018-8665 (Linking)
VI  - 226
IP  - 2
DP  - 2013
TI  - Subacute cutaneous lupus erythematosus induced and exacerbated by proton pump 
      inhibitors.
PG  - 119-23
LID - 10.1159/000346694 [doi]
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) can be induced by 
      numerous drugs. We report 3 cases of SCLE induced by proton pump inhibitors 
      (PPIs). OBJECTIVE: To highlight a rare cutaneous side effect induced by a 
      frequently prescribed drug such as a PPI. CASE REPORTS: Case 1 was a 30-year-old 
      man who developed multiple annular plaques over the trunk and lower limbs 1 month 
      after the initiation of pantoprazole. Antinuclear antibodies (ANA) were positive 
      with anti-Ro/SSA and anti-La/SSB antibodies, and histology confirmed the 
      diagnosis. Clinical improvement was achieved 8 weeks after the discontinuation of 
      pantoprazole and the introduction of a treatment combining topical steroids and 
      hydroxychloroquine. Lesions relapsed when pantoprazole was accidentally 
      rechallenged. The second case was a 31-year-old woman, 28 weeks pregnant, who 
      presented erythematous annular plaques over the trunk 7 weeks after starting 
      esomeprazole. ANA and anti-Ro/SSA antibodies were positive, and the histology was 
      compatible with SCLE. Fetal ultrasound was normal. She was treated with topical 
      and oral steroids and hydroxychloroquine. Clinical improvement was achieved 4 
      weeks after the discontinuation of esomeprazole. The third case was a 57-year-old 
      woman with systemic erythematosus lupus presenting annular and psoriasiform 
      lesions on the trunk for 15 months. She was treated successively with 
      hydroxychloroquine, azathioprine, mycophenolate mofetil and methotrexate with 
      prednisone. A review of her drug history revealed the introduction of omeprazole 
      a few weeks before the first appearance of skin lesions and omeprazole was 
      contraindicated. CONCLUSION: SCLE should systematically be suspected in case of 
      eruption after the introduction of PPI. The risk of fetal cardiac complications 
      is important in pregnant women.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Almebayadh, Mishal
AU  - Almebayadh M
AD  - Department of Dermatology (Pavillon Tarnier), Hopital Cochin, APHP, Universite 
      Rene Descartes, Paris, France.
FAU - Regnier-Rosencher, Elodie
AU  - Regnier-Rosencher E
FAU - Carlotti, Agnes
AU  - Carlotti A
FAU - Goulvestre, Claire
AU  - Goulvestre C
FAU - Le Guern, Veronique
AU  - Le Guern V
FAU - Mouthon, Luc
AU  - Mouthon L
FAU - Avril, Marie-Francoise
AU  - Avril MF
FAU - Dupin, Nicolas
AU  - Dupin N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130323
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - D8TST4O562 (Pantoprazole)
RN  - KG60484QX9 (Omeprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/adverse effects
MH  - Adult
MH  - Esomeprazole/adverse effects
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/pathology
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/adverse effects
MH  - Pantoprazole
MH  - Proton Pump Inhibitors/*adverse effects
EDAT- 2013/04/04 06:00
MHDA- 2014/12/24 06:00
CRDT- 2013/04/04 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/12/14 00:00 [accepted]
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/12/24 06:00 [medline]
AID - 000346694 [pii]
AID - 10.1159/000346694 [doi]
PST - ppublish
SO  - Dermatology. 2013;226(2):119-23. doi: 10.1159/000346694. Epub 2013 Mar 23.