PMID- 23549246
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20130603
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 100
IP  - 2
DP  - 2013 May
TI  - Elevated serum beta2-glycoprotein-I-lipoprotein(a) complexes levels are associated 
      with the presence and complications in type 2 diabetes mellitus.
PG  - 250-6
LID - S0168-8227(13)00080-6 [pii]
LID - 10.1016/j.diabres.2013.03.002 [doi]
AB  - AIMS: To examine the serum levels of beta2-glycoprotein I-lipoprotein(a) complexes 
      [beta2-GPI-Lp(a)] in type 2 diabetes mellitus (T2DM) patients and evaluate the 
      association of the complexes with complications in T2DM. METHODS: Fifty two T2DM 
      patients (22 with complications and 30 free of complications) and 52 
      age/gender-matched healthy controls were studied. Serum concentrations of 
      beta2-GPI-Lp(a) and ox-Lp(a) were measured by "sandwich" ELISAs and their 
      associations with complications were examined using multiple linear regression. 
      RESULTS: Mean serum beta2-GPI-Lp(a) (1.19 +/- 0.30 U/mL vs. 0.89 +/- 0.20 U/mL, p<0.001) 
      and ox-Lp(a) concentrations (13.34 +/- 11.73 mg/L vs. 5.26 +/- 3.34 mg/L, p<0.001) 
      were both significantly higher in T2DM than in controls. The area under the ROC 
      curve (AUC) for beta2-GPI-Lp(a) and ox-Lp(a) was 0.725 and 0.738, respectively. 
      beta2-GPI-Lp(a) levels were markedly higher in patients with complications than 
      those without complication (1.39 +/- 0.28 U/mL vs. 1.04 +/- 0.31 U/mL, p<0.01), 
      whereas no marked difference was found in ox-Lp(a). In multivariate regression 
      analysis, the association between beta2-GPI-Lp(a) and complications remained 
      significant (beta=0.249, p<0.05, respectively) after adjustments were made for other 
      traits. CONCLUSIONS: Elevated beta2-GPI-Lp(a) may reflect chronic underlying 
      pathophysiological processes involved in development of complications of T2DM.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Cheng
AU  - Wang C
AD  - Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, 
      Nanjing University, Nanjing, People's Republic of China.
FAU - Niu, Dong-Mei
AU  - Niu DM
FAU - Hu, Jing
AU  - Hu J
FAU - Guan, Xiao-Cui
AU  - Guan XC
FAU - Yang, Wen
AU  - Yang W
FAU - Wang, Jun-Jun
AU  - Wang JJ
FAU - Zhang, Chen-Yu
AU  - Zhang CY
FAU - Zhang, Chun-Ni
AU  - Zhang CN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130330
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Lipoprotein(a))
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Lipoprotein(a)/*blood
MH  - Male
MH  - Middle Aged
MH  - beta 2-Glycoprotein I/*blood
EDAT- 2013/04/04 06:00
MHDA- 2014/01/11 06:00
CRDT- 2013/04/04 06:00
PHST- 2012/11/30 00:00 [received]
PHST- 2013/02/16 00:00 [revised]
PHST- 2013/03/01 00:00 [accepted]
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - S0168-8227(13)00080-6 [pii]
AID - 10.1016/j.diabres.2013.03.002 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2013 May;100(2):250-6. doi: 
      10.1016/j.diabres.2013.03.002. Epub 2013 Mar 30.