PMID- 23549447
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 6
IP  - 3
DP  - 2013 May
TI  - Division of labor between lung dendritic cells and macrophages in the defense 
      against pulmonary infections.
PG  - 464-73
LID - 10.1038/mi.2013.14 [doi]
AB  - The lung is highly exposed to the external environment. For this reason, the lung 
      needs to handle a number of potential threats present in inhaled air such as 
      viruses or bacteria. Dendritic cells (DCs) and macrophages (MFs) play an 
      important role in orchestrating the immune responses to these challenges. The 
      severe lung inflammation caused by some pathogens poses a unique challenge to the 
      immune system: the potential insult must be eliminated rapidly whereas tissue 
      inflammation must be controlled in order to avoid collateral damages that can 
      lead to acute respiratory failure. Immune responses to infectious agents are 
      initiated and controlled by various populations of antigen-presenting cells with 
      specialized functions, which include conventional DCs (cDCs), monocyte-derived 
      DCs (moDCs), plasmacytoid DCs (pDCs), and alveolar MFs (AMFs). This review will 
      discuss the role of these different cells in responses to pulmonary infections, 
      with a focus on influenza virus and Mycobacterium tuberculosis.
FAU - Guilliams, M
AU  - Guilliams M
AD  - Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular 
      Biomedical Research, VIB, Ghent, Belgium. martin.guilliams@ugent.be
FAU - Lambrecht, B N
AU  - Lambrecht BN
FAU - Hammad, H
AU  - Hammad H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130403
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Lung/pathology
MH  - Macrophages, Alveolar/*immunology
MH  - Mycobacterium tuberculosis/*immunology
MH  - Orthomyxoviridae/*immunology
MH  - Orthomyxoviridae Infections/*immunology
MH  - Respiratory Tract Infections/*immunology
MH  - Tuberculosis, Pulmonary/*immunology
EDAT- 2013/04/04 06:00
MHDA- 2013/11/14 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - S1933-0219(22)01207-7 [pii]
AID - 10.1038/mi.2013.14 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2013 May;6(3):464-73. doi: 10.1038/mi.2013.14. Epub 2013 Apr 3.