PMID- 23549729
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20211021
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 65
IP  - 6
DP  - 2013 Jun
TI  - Current perspectives on the intensity of natural selection of MHC loci.
PG  - 479-83
LID - 10.1007/s00251-013-0693-x [doi]
AB  - Polymorphism of genes in the major histocompatibility complex (MHC) is believed 
      to be maintained by balancing selection. However, direct evidence of selection 
      has proven difficult to demonstrate. In 1994, Satta and colleagues estimated the 
      selection intensity of the human MHC (human leukocyte antigen (HLA)) loci; 
      however, at that time the number of HLA sequences was limited. By comparing five 
      different methods, this study demonstrated the best way to calculate the 
      selection coefficient, through a computer simulation study. Since the study, many 
      HLA nucleotide sequences have been made available. Our new analysis takes 
      advantage of these newly available sequences and compares new estimates with 
      those of the previous study. Generally, our new results are consistent with those 
      of the 1994 study. Our results show that, even after 20 years of exhaustive 
      sequencing of human HLA, the number of dominant HLA alleles, on which our 
      original estimate of selection intensity depended, appears to be conserved. 
      Indeed, according to the frequency distribution for each HLA allele, most 
      sequences in the database were minor or private alleles; therefore, we conclude 
      that the selection intensities of HLA loci are at most 4.4 % even though the HLA 
      is the prominent example on which the natural selection has been operating.
FAU - Yasukochi, Yoshiki
AU  - Yasukochi Y
AD  - Department of Evolutionary Studies of Biosystems, The Graduate University for 
      Advanced Studies (SOKENDAI), Shonan Village, Hayama, Kanagawa, Japan. 
      hyasukou@proof.ocn.ne.jp
FAU - Satta, Yoko
AU  - Satta Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130403
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Computer Simulation
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Polymorphism, Genetic
MH  - Selection, Genetic/*genetics
PMC - PMC3651823
EDAT- 2013/04/04 06:00
MHDA- 2013/09/21 06:00
PMCR- 2013/04/03
CRDT- 2013/04/04 06:00
PHST- 2012/12/29 00:00 [received]
PHST- 2013/03/05 00:00 [accepted]
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2013/04/03 00:00 [pmc-release]
AID - 693 [pii]
AID - 10.1007/s00251-013-0693-x [doi]
PST - ppublish
SO  - Immunogenetics. 2013 Jun;65(6):479-83. doi: 10.1007/s00251-013-0693-x. Epub 2013 
      Apr 3.