PMID- 23549806
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20211021
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 54
IP  - 3
DP  - 2013 May 1
TI  - Association of monocyte chemoattractant protein-1 (MCP-1) 2518A/G polymorphism 
      with proliferative diabetic retinopathy in Korean type 2 diabetes.
PG  - 621-5
LID - 10.3349/ymj.2013.54.3.621 [doi]
AB  - PURPOSE: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that can 
      increase adhesion molecule expression on monocytes and produce superoxide anions. 
      Hyperglycemia induces MCP-1 production in vascular endothelial cells and retinal 
      pigmented epithelial cells, and has been implicated as a causal factor in the 
      facilitation of vascular complications in diabetes. In the present study, we 
      evaluated the association of a single nucleotide polymorphism (SNP) in the MCP-1 
      gene with proliferative diabetic retinopathy (PDR) in a Korean population with 
      type 2 diabetes. MATERIALS AND METHODS: We conducted a case-control study, which 
      enrolled 590 subjects with type 2 diabetes, and SNP genotyping of c.2518A/G in 
      the MCP-1 gene was performed using polymerase chain reaction followed by 
      digestion with PvuII restriction enzyme. RESULTS: The prevalence of c.2518A/G 
      polymorphism in diabetic patients was 13.2% (A/A), 47.1% (A/G) and 39.7% (G/G). 
      In patients with diabetic retinopathy, the prevalence of PDR was significantly 
      higher (p=0.009) in diabetic subjects with the c.2518A/A genotype (35.9%; n=78) 
      compared to those with either the A/G or G/G genotype (22.3%, n=512). The 
      prevalence of any other micro and macro-complications, including nephropathy and 
      cerebrovascular events, were not different according to the c.2518A/G genotype. 
      CONCLUSION: Our new genetic findings suggest that the c.2518A/A genotype in MCP-1 
      could be used as a susceptibility gene to predispose Koreans exhibiting type 2 
      diabetes for the development of PDR.
FAU - Jeon, Hyun Jeong
AU  - Jeon HJ
AD  - Department of Internal Medicine, Chungbuk National University College of 
      Medicine, 776 1sunhwan-ro, Heungdeok-gu, Cheongju 361-711, Korea.
FAU - Choi, Hyung Jin
AU  - Choi HJ
FAU - Park, Byong Hee
AU  - Park BH
FAU - Lee, Yong Hee
AU  - Lee YH
FAU - Oh, Taekeun
AU  - Oh T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/etiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Republic of Korea
PMC - PMC3635614
OTO - NOTNLM
OT  - MCP-1 polymorphism
OT  - proliferative diabetic retinopathy
OT  - type 2 DM
COIS- The authors have no financial conflicts of interest.
EDAT- 2013/04/04 06:00
MHDA- 2014/01/07 06:00
PMCR- 2013/05/01
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - 201305621 [pii]
AID - 10.3349/ymj.2013.54.3.621 [doi]
PST - ppublish
SO  - Yonsei Med J. 2013 May 1;54(3):621-5. doi: 10.3349/ymj.2013.54.3.621.