PMID- 23550218
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130404
LR  - 20211021
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 7
DP  - 2013
TI  - CNS control of glucose metabolism: response to environmental challenges.
PG  - 20
LID - 10.3389/fnins.2013.00020 [doi]
LID - 20
AB  - Over the last 15 years, considerable work has accumulated to support the role of 
      the CNS in regulating postprandial glucose levels. As discussed in the first 
      section of this review, the CNS receives and integrates information from afferent 
      neurons, circulating hormones, and postprandially generated nutrients to 
      subsequently direct changes in glucose output by the liver and glucose uptake by 
      peripheral tissues. The second major component of this review focuses on the 
      effects of external pressures, including high fat diet and changes to the 
      light:dark cycle on CNS-regulating glucose homeostasis. We also discuss the 
      interaction between these different pressures and how they contribute to the 
      multifaceted mechanisms that we hypothesize contribute to the dysregulation of 
      glucose in type 2 diabetes mellitus (T2DM). We argue that while current 
      peripheral therapies serve to delay the progression of T2DM, generating combined 
      obesity and T2DM therapies targeted at the CNS, the primary site of dysfunction 
      for both diseases, would lead to a more profound impact on the progression of 
      both diseases.
FAU - Arble, Deanna M
AU  - Arble DM
AD  - Department of Medicine, University of Cincinnati Cincinnati, OH, USA.
FAU - Sandoval, Darleen A
AU  - Sandoval DA
LA  - eng
GR  - F32 DK097867/DK/NIDDK NIH HHS/United States
GR  - R01 DK082480/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130226
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3581798
OTO - NOTNLM
OT  - arcuate nucleus
OT  - brain
OT  - circadian
OT  - glucose metabolism
OT  - high fat diet
EDAT- 2013/04/04 06:00
MHDA- 2013/04/04 06:01
PMCR- 2013/01/01
CRDT- 2013/04/04 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/02/04 00:00 [accepted]
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/04/04 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2013.00020 [doi]
PST - epublish
SO  - Front Neurosci. 2013 Feb 26;7:20. doi: 10.3389/fnins.2013.00020. eCollection 
      2013.