PMID- 23550771
OWN - NLM
STAT- MEDLINE
DCOM- 20140319
LR  - 20130819
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 123
IP  - 9
DP  - 2013 Sep
TI  - The expression of hypoxia-inducible factor-1 in primary brain tumors.
PG  - 657-62
LID - 10.3109/00207454.2013.789874 [doi]
AB  - PURPOSE: Primary brain tumors are common type of neoplasms. The most common are 
      astrocytic tumors, so do meningiomas of various grades. The etiology is still 
      unknown; however, there are lots of data presenting new theories about genetic 
      alterations responsible for low- or high-grade astrocytic tumors development as 
      well as meningiomas, despite this the results are divergent. The aim of the study 
      was to evaluate hypoxia-inducible factor-1 (HIF-1) expression in meningiomas and 
      astrocytic tumors of various grades. MATERIAL AND METHODS: One hundred six cases 
      of astrocytic tumors were divided into diffused astrocytoma (24 cases), 
      anaplastic astrocytoma (40 cases) and glioblastoma groups (42 cases). Among 
      glioblastoma group, 30 cases were secondary glioblastoma. One hundred fifty-four 
      meningioma cases were divided as low-grade meningioma (G1: 104 cases) and 
      high-grade meningioma groups (G2: 43 cases and G3: 7 cases). Twelve low-grade 
      meningiomas transformed into high-grade tumors, 17 low-grade meningiomas recur 
      within 12 years. HIF-1 expression was estimated using immunohistochemistry under 
      the light microscope. Statistical analysis was performed in all examined groups. 
      RESULTS: HIF-1 expression was observed in 37.5% cases of diffused astrocytomas, 
      in anaplastic astrocytomas 27.5% tumors were HIF-1 positive, in the glioblastoma 
      goup HIF-1 expression was observed in 83.3% cases. All secondary glioblastomas 
      were positive for HIF-1. Low-grade meningiomas were positive for HIF-1 in 55.7%, 
      in high-grade meningiomas, HIF-1 expression was observed in 84%. All meningiomas, 
      which progressed from low- to high-grade meningiomas, were HIF-1 positive. 
      CONCLUSION: HIF-1 expression is associated with the development and progression 
      of both astrocytic tumors and meningiomas.
FAU - Reszec, Joanna
AU  - Reszec J
AD  - Department of Medical Pathomorphology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Rutkowski, Robert
AU  - Rutkowski R
FAU - Chyczewski, Lech
AU  - Chyczewski L
LA  - eng
PT  - Journal Article
DEP - 20130509
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Brain Neoplasms/classification/*metabolism/pathology
MH  - Female
MH  - Glioma/classification/*metabolism/pathology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Male
MH  - Meningeal Neoplasms/*metabolism/pathology
MH  - Meningioma/*metabolism/pathology
MH  - Middle Aged
EDAT- 2013/04/05 06:00
MHDA- 2014/03/22 06:00
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - 10.3109/00207454.2013.789874 [doi]
PST - ppublish
SO  - Int J Neurosci. 2013 Sep;123(9):657-62. doi: 10.3109/00207454.2013.789874. Epub 
      2013 May 9.