PMID- 23551926
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 110
IP  - 9
DP  - 2013 Nov 14
TI  - Resveratrol and fish oil reduce catecholamine-induced mortality in obese rats: 
      role of oxidative stress in the myocardium and aorta.
PG  - 1580-90
LID - 10.1017/S0007114513000925 [doi]
AB  - The exact mechanisms of the relationship between obesity and cardiovascular 
      events are not yet fully understood; however, oxidative stress may be involved. 
      Thus, the aim of the present study was to evaluate the effects of resveratrol and 
      fish oil on catecholamine-induced mortality in obese rats. To begin with, rats 
      were divided into five groups: (1) lean, (2) obese, (3) obese supplemented with 
      resveratrol, (4) obese supplemented with fish oil and (5) obese supplemented with 
      resveratrol and fish oil (n 18 rats per group), for 2 months. After 
      supplementation, the groups were subdivided as with (n 10) and without (n 8) 
      cardiovascular catecholaminergic stress after isoproterenol (60 mg/kg) injection. 
      At 24 h later, the survival rate was analysed. The obese group showed lower 
      survival rates (10 %) when compared with the lean group (70 %). On the other 
      hand, resveratrol (50 %) and fish oil (40 %) increased the survival rate of obese 
      rats (chi(2) test, P= 0.019). Biochemical analyses of the myocardium and aorta 
      revealed that obese rats had higher levels of superoxide and oxidative damage to 
      lipids and protein. This was associated with reduced superoxide dismutase and 
      glutathione peroxidase activity in both the myocardium and aorta. The 
      supplementation increased antioxidant enzyme activities and reduced oxidative 
      damage. We also evaluated the nuclear factor-erythroid 2 p45-related factor 2 
      (Nrf2)/Kelch-like ECH-associated protein 1 antioxidant pathway. Nrf2 protein 
      levels that were reduced in obese rats were increased by the antioxidant 
      treatment. Taken together, these results showed that resveratrol and fish oil 
      reduce catecholamine-induced mortality in obese rats, partly through the 
      reduction of oxidative stress.
FAU - Avila, Pricila R M
AU  - Avila PR
AD  - Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, 
      Universidade do Extremo Sul Catarinense, 88806-000 Criciuma, SC, Brazil.
FAU - Marques, Scherolin O
AU  - Marques SO
FAU - Luciano, Thais F
AU  - Luciano TF
FAU - Vitto, Marcelo F
AU  - Vitto MF
FAU - Engelmann, Julia
AU  - Engelmann J
FAU - Souza, Daniela R
AU  - Souza DR
FAU - Pereira, Sane V
AU  - Pereira SV
FAU - Pinho, Ricardo A
AU  - Pinho RA
FAU - Lira, Fabio S
AU  - Lira FS
FAU - De Souza, Claudio T
AU  - De Souza CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130404
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Antioxidants)
RN  - 0 (Catecholamines)
RN  - 0 (Dietary Fats)
RN  - 0 (Fish Oils)
RN  - 0 (KLHL1 protein, mouse)
RN  - 0 (Microfilament Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Stilbenes)
RN  - L628TT009W (Isoproterenol)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology/therapeutic use
MH  - Aorta/drug effects/*metabolism
MH  - Catecholamines/*metabolism/pharmacology
MH  - Dietary Fats/pharmacology/therapeutic use
MH  - Dietary Supplements
MH  - Fish Oils/pharmacology/*therapeutic use
MH  - Isoproterenol/metabolism/pharmacology
MH  - Male
MH  - Microfilament Proteins/metabolism
MH  - Myocardium/*metabolism
MH  - NF-E2-Related Factor 2/metabolism
MH  - Obesity/*drug therapy/metabolism/mortality
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol
MH  - Stilbenes/pharmacology/*therapeutic use
EDAT- 2013/04/05 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - S0007114513000925 [pii]
AID - 10.1017/S0007114513000925 [doi]
PST - ppublish
SO  - Br J Nutr. 2013 Nov 14;110(9):1580-90. doi: 10.1017/S0007114513000925. Epub 2013 
      Apr 4.