PMID- 23552098
OWN - NLM
STAT- MEDLINE
DCOM- 20140801
LR  - 20140304
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 92
IP  - 2
DP  - 2014 Mar
TI  - Retinal and choroidal intravascular spectral-domain optical coherence tomography.
PG  - 126-32
LID - 10.1111/aos.12048 [doi]
AB  - PURPOSE: To examine retinal and choroidal blood vessels using spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: Retrospective case series. 
      RESULTS: Scans through retinal blood vessels in healthy subjects demonstrated 
      vessel wall reflexes and a tri-layer profile of the blood column on longitudinal 
      scans and a figure-of-eight configuration on cross-sectional scans. Intravascular 
      reflectivity decreased with increasingly oblique angles of observation and was 
      absent when blood flow was parallel to the line of sight. The high blood flow in 
      the choroidal vessels in healthy subjects and the low flow in the retinal vessels 
      in patients with ocular ischaemic syndrome and central retinal artery occlusion 
      were both associated with lower reflectivity of the blood and an unstructured 
      intravascular SD-OCT profile. DISCUSSION: This qualitative in vivo study found a 
      characteristically structured SD-OCT profile of the blood column in retinal 
      vessels with normal blood flow. Both structure and total reflectivity faded when 
      blood flow was lower or higher than normal or at oblique angles to the line of 
      sight. In conclusion, SD-OCT scans of the vessels in the posterior pole of the 
      eye may assist the clinical assessment of gross abnormalities of ocular blood 
      flow, e.g. in carotid artery stenosis.
CI  - (c) 2013 The Authors Acta Ophthalmologica (c) 2013 Acta Ophthalmologica Scandinavica 
      Foundation.
FAU - Willerslev, Anne
AU  - Willerslev A
AD  - Department of Ophthalmology, Glostrup Hospital, Glostrup, DenmarkFaculty of 
      Health Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of 
      Ophthalmology, Roskilde Hospital, Roskilde, Denmark.
FAU - Li, Xiao Q
AU  - Li XQ
FAU - Cordtz, Peter
AU  - Cordtz P
FAU - Munch, Inger C
AU  - Munch IC
FAU - Larsen, Michael
AU  - Larsen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130401
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity/physiology
MH  - Child
MH  - Choroid/*blood supply
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Ischemia/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Regional Blood Flow/physiology
MH  - Retinal Artery Occlusion/*physiopathology
MH  - Retinal Vessels/*physiology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - blood flow imaging
OT  - central retinal artery occlusion
OT  - choroidal blood flow
OT  - in vivo
OT  - ocular ischemic syndrome
OT  - optical coherence tomography
OT  - red blood cell alignment
OT  - retinal blood flow
OT  - shear rate
EDAT- 2013/04/05 06:00
MHDA- 2014/08/02 06:00
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2014/08/02 06:00 [medline]
AID - 10.1111/aos.12048 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2014 Mar;92(2):126-32. doi: 10.1111/aos.12048. Epub 2013 Apr 1.