PMID- 23552821
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220410
IS  - 1932-0620 (Print)
IS  - 1935-3227 (Electronic)
IS  - 1932-0620 (Linking)
VI  - 7
IP  - 2
DP  - 2013 Mar-Apr
TI  - Eight weeks of exercise training improves fitness measures in 
      methamphetamine-dependent individuals in residential treatment.
PG  - 122-8
LID - 10.1097/ADM.0b013e318282475e [doi]
AB  - OBJECTIVES: Physical exercise has been shown to benefit diverse medical and 
      behavioral conditions. This study assesses the feasibility and efficacy of an 
      8-week endurance and resistance training program on fitness measures in 
      individuals undergoing residential treatment for methamphetamine (MA) dependence. 
      METHODS: A total of 39 MA-dependent individuals were randomized to 3 days/week of 
      exercise training (ET, n = 15) or health education without training (equal 
      attention [EA], n = 14) over 8 weeks. Aerobic performance ((Equation is included 
      in full-text article.)VO2max) was measured by indirect calorimetry, body 
      composition by skinfolds, muscle strength by 1-repetition maximum (1-RM), and 
      endurance at 85% of 1-RM for both leg press (LP) and chest press (CP). RESULTS: A 
      total of 29 individuals completed the study for a 74% adherence rate. Baseline 
      characteristics (mean +/- SD) were balanced between groups: age 31 +/- 7 years; 
      height = 1.74 +/- 0.07 m; weight 82.0 +/- 15.0 kg. The ET group significantly 
      improved (Equation is included in full-text article.)O2max by 0.63 +/- 0.22 L/min 
      (+21%), LP strength by 24.4 +/- 5.6 kg (+40%), and CP strength by 20.6 +/- 5.7 kg 
      (+49%). The ET group increased LP and CP endurance by 120% and 96%, respectively 
      and showed significant reductions in body weight of 1.7 +/- 2.4 kg (-2%), % body 
      fat of 2.8 +/- 1.3% (-15%), and fat weight 2.8 +/- 1.8 kg (-18%). All changes were 
      significant (P < 0.001) for ET, and no changes were seen for the EA group. 
      CONCLUSIONS: Individuals recovering from MA dependence showed substantial 
      improvements in aerobic exercise performance, muscle strength and endurance, and 
      body composition with ET. These findings demonstrate the feasibility of an ET 
      intervention in these participants and also show excellent responsiveness to the 
      exercise stimulus resulting in physiological changes that might enhance recovery 
      from drug dependency.
FAU - Dolezal, Brett A
AU  - Dolezal BA
AD  - Exercise Physiology Research Laboratory, David Geffen School of Medicine, 
      University of California, Los Angeles, CA 90095, USA. bdolezal@mednet.ucla.edu
FAU - Chudzynski, Joy
AU  - Chudzynski J
FAU - Storer, Thomas W
AU  - Storer TW
FAU - Abrazado, Marlon
AU  - Abrazado M
FAU - Penate, Jose
AU  - Penate J
FAU - Mooney, Larissa
AU  - Mooney L
FAU - Dickerson, Daniel
AU  - Dickerson D
FAU - Rawson, Richard A
AU  - Rawson RA
FAU - Cooper, Christopher B
AU  - Cooper CB
LA  - eng
GR  - R01 DA027633/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - J Addict Med
JT  - Journal of addiction medicine
JID - 101306759
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine-Related Disorders/*therapy
MH  - Body Composition/physiology
MH  - Calorimetry, Indirect/methods/statistics & numerical data
MH  - Central Nervous System Stimulants
MH  - Exercise/physiology
MH  - Feasibility Studies
MH  - Female
MH  - Health Behavior
MH  - Health Education/methods
MH  - Humans
MH  - Male
MH  - *Methamphetamine
MH  - Middle Aged
MH  - Muscle Strength/physiology
MH  - Patient Compliance/statistics & numerical data
MH  - Physical Endurance/*physiology
MH  - Physical Fitness/*physiology
MH  - Residential Treatment/*methods
MH  - Resistance Training/*methods
MH  - Treatment Outcome
MH  - Weight Lifting/statistics & numerical data
MH  - Young Adult
PMC - PMC3617407
MID - NIHMS435284
EDAT- 2013/04/05 06:00
MHDA- 2013/07/10 06:00
PMCR- 2014/03/01
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 01271255-201303000-00007 [pii]
AID - 10.1097/ADM.0b013e318282475e [doi]
PST - ppublish
SO  - J Addict Med. 2013 Mar-Apr;7(2):122-8. doi: 10.1097/ADM.0b013e318282475e.