PMID- 23553469
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20211021
IS  - 2095-0225 (Electronic)
IS  - 2095-0217 (Linking)
VI  - 7
IP  - 2
DP  - 2013 Jun
TI  - From gut changes to type 2 diabetes remission after gastric bypass surgeries.
PG  - 191-200
LID - 10.1007/s11684-013-0258-2 [doi]
AB  - Increasing evidence suggests that the gut may influence the host's metabolism and 
      ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the 
      evidence on the relationship between the gut and T2DM remission after gastric 
      bypass surgery, and discuss the potential mechanisms underlying the above 
      relationship: gut anatomical rearrangement, microbial composition changes, 
      altered gut cells, and gut hormone modulation. However, the exact changes and 
      their relative importance in the metabolic improvements after gastric bypass 
      surgery remain to be further clarified. Elucidating the precise metabolic 
      mechanisms of T2DM resolution after bypass surgery will help to reveal the 
      molecular mechanisms of pathogenesis, and facilitate the development of novel 
      diagnoses and preventative interventions for this common disease.
FAU - Li, Bing
AU  - Li B
AD  - Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research 
      Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, CAS, 
      Shanghai, China.
FAU - Zhou, Xinrong
AU  - Zhou X
FAU - Wu, Jiarui
AU  - Wu J
FAU - Zhou, Huarong
AU  - Zhou H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130404
PL  - China
TA  - Front Med
JT  - Frontiers of medicine
JID - 101549428
RN  - 0 (Insulin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*metabolism/surgery
MH  - Gastric Bypass/*methods
MH  - Gastrointestinal Tract/*metabolism/surgery
MH  - Humans
MH  - Insulin/metabolism
MH  - Obesity/metabolism/*surgery
MH  - Remission Induction
EDAT- 2013/04/05 06:00
MHDA- 2014/02/15 06:00
CRDT- 2013/04/05 06:00
PHST- 2012/10/11 00:00 [received]
PHST- 2013/01/14 00:00 [accepted]
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
AID - 10.1007/s11684-013-0258-2 [doi]
PST - ppublish
SO  - Front Med. 2013 Jun;7(2):191-200. doi: 10.1007/s11684-013-0258-2. Epub 2013 Apr 
      4.