PMID- 23553784
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20211021
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 5
DP  - 2013 Nov
TI  - MRI-based prediction of pulsed high-intensity focused ultrasound effect on tissue 
      transport in rabbit muscle.
PG  - 1094-102
LID - 10.1002/jmri.24087 [doi]
AB  - PURPOSE: To design an algorithm for optimizing pulsed high intensity focused 
      ultrasound (p-HIFU) treatment parameters to maximize tissue transport while 
      minimizing thermal necrosis based on MR image guidance. MATERIALS AND METHODS: 
      P-HIFU power, duty cycle, and treatment duration were varied to generate 
      different levels of thermal and mechanical deposition in rabbit muscle. Changes 
      in T2-weighted and T1 contrast-enhanced (CE) signal were assessed immediately 
      following treatment and at 24 h. Transport parameters were extracted by means of 
      T1-weighted dynamic contrast-enhanced MRI (DCE-MRI) technique at 0 and 24-h time 
      points. RESULTS: Successful p-HIFU treatment was indicated by focal 
      hyperintensity on the T2-weighted image immediately post-treatment, suggesting 
      increased fluid (edema), with little intensity change in CE image. After 24 h, 
      the affected region expanded along the muscle fiber accompanied by clear 
      hyperintensity in CE image (contrast uptake). Quantitative DCE-MRI analysis 
      revealed statistically significant increases in both leakage rate and 
      extracellular space, accompanied by a decrease in clearance rate. CONCLUSION: 
      Successful p-HIFU treatment was mainly correlated to tissue heating. Tissue 
      transport properties following treatment success would result in improved contact 
      between drug and targets in both time and space. MRI is the key to controlling 
      treatment by means of thermometry and also monitoring efficacy by means of 
      T2-weighted imaging.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - O'Neill, Brian E
AU  - O'Neill BE
AD  - Department of Translational Imaging, The Methodist Hospital Research Institute, 
      Houston, Texas, USA.
FAU - Vo, Howard Q
AU  - Vo HQ
FAU - Shao, Hongwei
AU  - Shao H
FAU - Karmonik, Christof
AU  - Karmonik C
FAU - Zhou, Xiaobo
AU  - Zhou X
FAU - Li, King C
AU  - Li KC
LA  - eng
GR  - R01 EB009009/EB/NIBIB NIH HHS/United States
GR  - U01 CA166886/CA/NCI NIH HHS/United States
GR  - 5R01EB009009/EB/NIBIB NIH HHS/United States
GR  - U01 CA166886-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130401
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - *Algorithms
MH  - Animals
MH  - Body Temperature
MH  - Female
MH  - High-Intensity Focused Ultrasound Ablation/*methods
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Muscle, Skeletal/pathology/*physiopathology/*surgery
MH  - Rabbits
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Surgery, Computer-Assisted/*methods
MH  - Thermal Conductivity
MH  - Treatment Outcome
PMC - PMC3706525
MID - NIHMS443044
OTO - NOTNLM
OT  - MRI-guided focused ultrasound
OT  - clearance rate
OT  - drug delivery
OT  - dynamic contrast enhanced-MRI
OT  - pulsed high-intensity focused ultrasound
OT  - tissue permeability
EDAT- 2013/04/05 06:00
MHDA- 2014/06/06 06:00
PMCR- 2014/11/01
CRDT- 2013/04/05 06:00
PHST- 2012/11/05 00:00 [received]
PHST- 2013/01/29 00:00 [accepted]
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - 10.1002/jmri.24087 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Nov;38(5):1094-102. doi: 10.1002/jmri.24087. Epub 2013 
      Apr 1.