PMID- 23554492
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 14
DP  - 2013 Apr 3
TI  - BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic 
      branching.
PG  - 6112-22
LID - 10.1523/JNEUROSCI.4630-12.2013 [doi]
AB  - Dendritic arborization of neurons is regulated by brain-derived neurotrophic 
      factor (BDNF) together with its receptor, TrkB. Endocytosis is required for 
      dendritic branching and regulates TrkB signaling, but how postendocytic 
      trafficking determines the neuronal response to BDNF is not well understood. The 
      monomeric GTPase Rab11 regulates the dynamics of recycling endosomes and local 
      delivery of receptors to specific dendritic compartments. We investigated whether 
      Rab11-dependent trafficking of TrkB in dendrites regulates BDNF-induced dendritic 
      branching in rat hippocampal neurons. We report that TrkB in dendrites is a cargo 
      for Rab11 endosomes and that both Rab11 and its effector, MyoVb, are required for 
      BDNF/TrkB-induced dendritic branching. In addition, BDNF induces the accumulation 
      of Rab11-positive endosomes and GTP-bound Rab11 in dendrites and the expression 
      of a constitutively active mutant of Rab11 is sufficient to increase dendritic 
      branching by increasing TrkB localization in dendrites and enhancing 
      sensitization to endogenous BDNF. We propose that Rab11-dependent dendritic 
      recycling provides a mechanism to retain TrkB in dendrites and to increase local 
      signaling to regulate arborization.
FAU - Lazo, Oscar M
AU  - Lazo OM
AD  - Neuronal Cell Biology and Regeneration Laboratory, Millennium Nucleus of 
      Regenerative Biology, Center of Aging and Regeneration, Departamento de 
      Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago CP 8331010, Chile.
FAU - Gonzalez, Andres
AU  - Gonzalez A
FAU - Ascano, Maria
AU  - Ascano M
FAU - Kuruvilla, Rejji
AU  - Kuruvilla R
FAU - Couve, Andres
AU  - Couve A
FAU - Bronfman, Francisca C
AU  - Bronfman FC
LA  - eng
GR  - R01 MH080738/MH/NIMH NIH HHS/United States
GR  - R01 NS073751/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 0 (MAP2 protein, rat)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Myo5b protein, rat)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Thiazolidines)
RN  - 0 (Wdr44 protein, rat)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.4.1 (Myosins)
RN  - SRQ9WWM084 (latrunculin A)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Bridged Bicyclo Compounds, Heterocyclic/pharmacology
MH  - Carbazoles/pharmacology
MH  - Cells, Cultured
MH  - Dendrites/*drug effects/physiology/ultrastructure
MH  - Embryo, Mammalian
MH  - Endocytosis/drug effects
MH  - Endosomes/*drug effects/ultrastructure
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - GTP-Binding Proteins/genetics/immunology/*metabolism
MH  - Gene Expression Regulation/drug effects/genetics
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Guanosine Triphosphate/metabolism
MH  - Hippocampus/cytology
MH  - Indole Alkaloids/pharmacology
MH  - Male
MH  - Microscopy, Confocal
MH  - Microtubule-Associated Proteins/metabolism
MH  - Mutation/genetics
MH  - Myosins/metabolism
MH  - Neurons/*cytology/drug effects
MH  - RNA, Small Interfering/pharmacology
MH  - Rats
MH  - Receptor, trkB/metabolism
MH  - Thiazolidines/pharmacology
MH  - Transfection
PMC - PMC3684039
MID - NIHMS463472
EDAT- 2013/04/05 06:00
MHDA- 2013/05/29 06:00
PMCR- 2013/10/03
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PHST- 2013/10/03 00:00 [pmc-release]
AID - 33/14/6112 [pii]
AID - 3829737 [pii]
AID - 10.1523/JNEUROSCI.4630-12.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Apr 3;33(14):6112-22. doi: 10.1523/JNEUROSCI.4630-12.2013.