PMID- 23554785
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130405
LR  - 20211021
IS  - 1674-8301 (Print)
IS  - 1674-8301 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Nov
TI  - Serum IL-10 from systemic lupus erythematosus patients suppresses the 
      differentiation and function of monocyte-derived dendritic cells.
PG  - 456-66
LID - 10.7555/JBR.26.20120115 [doi]
AB  - The role played by cytokines, other than interferon (IFN)-alpha, in the 
      differentiation and function of dendritic cells (DCs) in systemic lupus 
      erythematosus (SLE), remains unclear. Serum interleukin-10 (IL-10) levels are 
      generally elevated in SLE patients, which might modulate the differentiation of 
      DCs. In this study, DCs were induced from monocytes either by transendothelial 
      trafficking or by culture with granulocyte-macrophage colony-stimulating factor 
      (GM-CSF) + IL-4 + tumor necrosis factor (TNF)-alpha. Both systems were used to 
      investigate the effects of elevated serum IL-10 level on DC differentiation in 
      SLE patients. The results showed that monocyte-derived DCs induced by either SLE 
      serum or exogenous IL-10 reduced the expression of human leukocyte antigen 
      (HLA)-DR and CD80, decreased IL-12p40 level, and increased IL-10 level, and 
      exhibited an impaired capacity to stimulate allogenic T-cell proliferation. These 
      results indicate that serum IL-10 may be involved in the pathogenesis of SLE by 
      modulating the differentiation and function of DCs.
FAU - Sun, Zhida
AU  - Sun Z
AD  - Department of Oral Mucosal Diseases, the Affiliated Stomatological Hospital, 
      Nanjing Medical University, Nanjing, Jiangsu 210029, China;
FAU - Zhang, Rong
AU  - Zhang R
FAU - Wang, Huijuan
AU  - Wang H
FAU - Jiang, Pengtao
AU  - Jiang P
FAU - Zhang, Jiangquan
AU  - Zhang J
FAU - Zhang, Mingshun
AU  - Zhang M
FAU - Gu, Lei
AU  - Gu L
FAU - Yang, Xiaofan
AU  - Yang X
FAU - Zhang, Miaojia
AU  - Zhang M
FAU - Ji, Xiaohui
AU  - Ji X
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - China
TA  - J Biomed Res
JT  - Journal of biomedical research
JID - 101551157
PMC - PMC3597043
OTO - NOTNLM
OT  - dendritic cells (DCs)
OT  - differentiation
OT  - interleukin-10 (IL-10)
OT  - lupus erythematosus systemic (SLE)
COIS- The authors declared no financial conflict of interests.
EDAT- 2013/04/05 06:00
MHDA- 2013/04/05 06:01
PMCR- 2012/11/01
CRDT- 2013/04/05 06:00
PHST- 2011/10/09 00:00 [received]
PHST- 2011/12/21 00:00 [revised]
PHST- 2012/08/29 00:00 [accepted]
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2013/04/05 06:01 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - jbr-26-06-456 [pii]
AID - 10.7555/JBR.26.20120115 [doi]
PST - ppublish
SO  - J Biomed Res. 2012 Nov;26(6):456-66. doi: 10.7555/JBR.26.20120115. Epub 2012 Oct 
      31.