PMID- 23556085
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130405
LR  - 20211021
IS  - 2040-6207 (Print)
IS  - 2040-6215 (Electronic)
IS  - 2040-6207 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jun
TI  - High Prevalence of Obesity in Acute Promyelocytic Leukemia (APL): Implications 
      for Differentiating Agents in APL and Metabolic Syndrome.
PG  - 141-5
LID - 10.1177/2040620711408490 [doi]
AB  - BACKGROUND: Between January 1999 and December 2008, 469 patients treated for 
      acute myeloid leukemia (AML) were included in this single-institution study. 
      METHODS: We performed a case-control analysis to study the rate of obesity among 
      patients with acute promyelocytic leukemia (APL) and non-APL AML. RESULTS: A 
      total of 81% of APL patients analyzed were obese compared with 41.7% in the 
      non-APL group (p < 0.001). Body mass index (BMI) >30 was seen in 57% of APL 
      patients compared with 31% for the non-APL group (p = 0.01). Neither obesity nor 
      the chemotherapy dosing based on ideal body weight affected survival. 
      CONCLUSIONS: Our findings generate the hypothesis that APL and metabolic 
      syndromes may share a common pathogenic pathway via retinoic acid receptors 
      (RARs), the ligand-controlled transcription factors that function as heterodimers 
      with retinoid X receptors (RXRs) to regulate cell growth and survival. If this 
      link is confirmed in larger studies, our data will instigate further studies 
      using RXR and RAR modulators as a preventive strategy among obese individuals.
FAU - Tedesco, Jason
AU  - Tedesco J
AD  - Department of Pathology, Division of Hematology and Oncology, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
FAU - Qualtieri, Julianne
AU  - Qualtieri J
FAU - Head, David
AU  - Head D
FAU - Savani, Bipin N
AU  - Savani BN
FAU - Reddy, Nishitha
AU  - Reddy N
LA  - eng
GR  - K12 CA090625/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Ther Adv Hematol
JT  - Therapeutic advances in hematology
JID - 101549589
PMC - PMC3573402
OTO - NOTNLM
OT  - RAR
OT  - RXR
OT  - acute promyelocytic leukemia
OT  - body mass index
OT  - obesity
OT  - prevention
COIS- None declared.
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
PMCR- 2011/06/01
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - 10.1177_2040620711408490 [pii]
AID - 10.1177/2040620711408490 [doi]
PST - ppublish
SO  - Ther Adv Hematol. 2011 Jun;2(3):141-5. doi: 10.1177/2040620711408490.