PMID- 23558878
OWN - NLM
STAT- MEDLINE
DCOM- 20140808
LR  - 20220317
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 20
IP  - 2
DP  - 2013
TI  - Acute myocardial infarction due to left main coronary artery disease: a large 
      multicenter national registry.
PG  - 190-6
LID - 10.5603/CJ.2013.0033 [doi]
AB  - BACKGROUND: Optimal management of patients with acute myocardial infarction (MI) 
      due to critical stenosis of an unprotected left main coronary artery (ULMCA) is 
      not established. However, data from observational studies and registries 
      encourage to perform percutaneous coronary intervention (PCI) in high risk 
      patients. We investigated gender-related discrepancies, clinical course and 
      prognosis in patients with acute MI and ULMCA as an infarct-related artery. 
      METHODS: A total of 643 consecutive patients (184 [28.6%] females and 459 [71.4%] 
      males) with acute MI due to critical ULMCA stenosis were selected from the 
      population of 121,526 patients hospitalized due to acute coronary syndromes 
      between 2003 and 2006. The primary endpoints were in-hospital, 30-day, 6-month 
      and 12-month mortality. RESULTS: Women were older than men with significantly 
      higher proportion of women older than 65 and with unfavorable risk profile. The 
      management in men and women was similar. There was no significant gender-related 
      differences in mortality in all follow-up periods. In multivariate analysis 
      cardiogenic shock, pulmonary edema, ST elevation myocardial infarction (STEMI) 
      and advanced age significantly increased mortality, whereas successful PCI 
      decreased mortality. CONCLUSIONS: No significant differences in clinical course, 
      treatment and prognosis between men and women were noted. Mortality remained very 
      high in both genders. The most unfavorable prognostic factors were cardiogenic 
      shock, pulmonary edema, STEMI and advanced age. Percutaneous coronary angioplasty 
      is feasible and offers high success rate in this subset of patients.
FAU - Sadowski, Marcin
AU  - Sadowski M
AD  - Swietokrzyskie Cardiology Center, Kielce, Poland. emsad@o2.pl.
FAU - Gutkowski, Wojciech
AU  - Gutkowski W
FAU - Janion-Sadowska, Agnieszka
AU  - Janion-Sadowska A
FAU - Gasior, Mariusz
AU  - Gasior M
FAU - Gierlotka, Marek
AU  - Gierlotka M
FAU - Janion, Marianna
AU  - Janion M
FAU - Polonski, Lech
AU  - Polonski L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Angioplasty, Balloon, Coronary
MH  - Coronary Artery Disease/*complications/diagnosis/mortality/therapy
MH  - Coronary Stenosis/*complications/diagnosis/mortality/therapy
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/*etiology/mortality/therapy
MH  - Poland/epidemiology
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2013/04/06 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/04/06 06:00
PHST- 2013/04/05 00:00 [received]
PHST- 2013/04/05 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - VM/OJS/J/33972 [pii]
AID - 10.5603/CJ.2013.0033 [doi]
PST - ppublish
SO  - Cardiol J. 2013;20(2):190-6. doi: 10.5603/CJ.2013.0033.