PMID- 23559219
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220311
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 228
IP  - 4
DP  - 2013 Aug
TI  - Effects of prenatal exposure to atypical antipsychotics on postnatal development 
      and growth of infants: a case-controlled, prospective study.
PG  - 577-84
LID - 10.1007/s00213-013-3060-6 [doi]
AB  - OBJECTIVE: This study aims to investigate the developmental effects of atypical 
      antipsychotics on infants who were born to mothers taking an atypical 
      antipsychotic throughout pregnancy. METHOD: The developmental progress of 76 
      infants who experienced fetal exposure to atypical antipsychotics was compared to 
      that of 76 matched control infants who had no fetal exposure to any 
      antipsychotics. Planned assessment included Apgar score, body weight, height, and 
      the cognitive, language, motor, social-emotional, and adaptive behavior composite 
      scores of the Bayley Scales of Infant and Toddler Development, third edition 
      (BSID-III). Student's t test and Chi-square analysis were used as appropriate. 
      Repeated measurements were evaluated by analysis of covariance. RESULTS: At 2 
      months of age, the mean composite scores of cognitive, motor, social-emotional, 
      and adaptive behavior of BSID-III were significantly lower in atypical 
      antipsychotic-exposed infants than the controls. More atypical 
      antipsychotic-exposed infants had delayed development in cognitive, motor, 
      social-emotional, and adaptive behavior domains as defined by the composite score 
      of <85 in these subscales of BSID-III. At 12 months of age, there were no 
      significant differences between the two groups in all mean composite scores of 
      BSID-III. More atypical antipsychotic-exposed infants had low birth weight than 
      the controls (13.2 vs. 2.6 %, P = 0.031), although there were no significant 
      difference in mean birth weight and height between the two groups. CONCLUSION: 
      Fetal exposure to atypical antipsychotics may cause short-term delayed 
      development in cognitive, motor, social-emotional, and adaptive behavior, but not 
      in language, body weight, or height.
FAU - Peng, Mei
AU  - Peng M
AD  - Department of Obstetrical of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha, 410011, Hunan, People's Republic 
      of China.
FAU - Gao, Keming
AU  - Gao K
FAU - Ding, Yiling
AU  - Ding Y
FAU - Ou, Jianjun
AU  - Ou J
FAU - Calabrese, Joseph R
AU  - Calabrese JR
FAU - Wu, Renrong
AU  - Wu R
FAU - Zhao, Jingping
AU  - Zhao J
LA  - eng
SI  - ClinicalTrials.gov/NCT01479400
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20130405
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Apgar Score
MH  - Birth Weight/drug effects
MH  - Case-Control Studies
MH  - Child Development/*drug effects
MH  - Cognition/drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Complications/drug therapy/physiopathology
MH  - Prenatal Exposure Delayed Effects/*epidemiology
MH  - Prospective Studies
MH  - Schizophrenia/complications/*drug therapy
MH  - Time Factors
EDAT- 2013/04/06 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/04/06 06:00
PHST- 2012/07/28 00:00 [received]
PHST- 2013/03/04 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s00213-013-3060-6 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2013 Aug;228(4):577-84. doi: 
      10.1007/s00213-013-3060-6. Epub 2013 Apr 5.