PMID- 23559419
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20191210
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 6
DP  - 2013 Dec
TI  - Validation of sub-segmental visual scoring for the quantification of ischemic and 
      nonischemic myocardial fibrosis using late gadolinium enhancement MRI.
PG  - 1369-76
LID - 10.1002/jmri.24116 [doi]
AB  - PURPOSE: To determine the accuracy and reproducibility of late gadolinium 
      enhancement (LGE) MRI scar quantification using visual sub-segmental analysis 
      (VSSA) versus signal threshold-based analysis in ischemic and nonischemic 
      cardiomyopathy. MATERIALS AND METHODS: One-hundred sixty-one patients with 
      abnormal LGE imaging underwent VSSA and signal threshold-based analysis. VSSA was 
      performed using a 68 sub-segmental model. Signal threshold-based analysis was 
      performed using cutoffs of >/=2, >/=3, and >/=5 standard deviations (SD) above the mean 
      signal of normal myocardium. Comparison of VSSA and signal threshold-based 
      analysis was performed by linear regression and Bland Altman plots. RESULTS: 
      Seventy (44%) patients had ischemic scar, 76 (47%) had nonischemic scar, and 15 
      (9%) had a combined pattern. Correlation coefficients for VSSA versus signal 
      threshold-based analysis at >/=2, >/=3, and >/=5SD thresholds were r = 0.63, r = 0.79, 
      r = 0.81 (P < 0.001) for all patients, r = 0.74, r = 0.81, r = 0.81 (P < 0.001) 
      in those with ischemic scar, and r = 0.46, r = 0.69, r = 0.72 (P < 0.001) in 
      those with nonischemic scar. Bland Altman analysis revealed no significant bias 
      in total scar volume among all patients (-4.3 +/- 7.9%), those with ischemic scar 
      (-4.8 +/- 7.8%), or those with nonischemic scar (-2.6 +/- 7.6%). Intra-observer and 
      inter-observer variability of the VSSA technique was excellent with a mean 
      difference in total percent scar of 0.3% (-8.3-8.9%) and -0.4% (-9.5-8.5%), 
      respectively. CONCLUSION: A VSSA-based model of myocardial scar quantification is 
      accurate and reproducible in ischemic and nonischemic cardiomyopathy.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Fine, Nowell M
AU  - Fine NM
AD  - Division of Cardiology, Department of Medicine, Schulich School of Medicine and 
      Dentistry, University of Western Ontario, London, Ontario, Canada.
FAU - Tandon, Shruti
AU  - Tandon S
FAU - Kim, Han W
AU  - Kim HW
FAU - Shah, Dipan J
AU  - Shah DJ
FAU - Thompson, Terry
AU  - Thompson T
FAU - Drangova, Maria
AU  - Drangova M
FAU - White, James A
AU  - White JA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20130404
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Cardiomyopathies/*complications/*pathology
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium/administration & dosage
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications/*pathology
MH  - Myocardium/*pathology
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - late gadolinium enhancement
OT  - magnetic resonance imaging
OT  - quantitative analysis
OT  - visual quantification
EDAT- 2013/04/06 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/04/06 06:00
PHST- 2011/12/16 00:00 [received]
PHST- 2013/02/13 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - 10.1002/jmri.24116 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Dec;38(6):1369-76. doi: 10.1002/jmri.24116. Epub 2013 
      Apr 4.