PMID- 23559899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130408
LR  - 20211021
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 13
IP  - 1
DP  - 2013 Feb
TI  - Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and 
      Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar 
      Typhimurium Expressing Chicken Interleukin-18.
PG  - 34-41
LID - 10.4110/in.2013.13.1.34 [doi]
AB  - Interleukin-18 (IL-18) has been known to induce interferon-gamma (IFN-gamma) production 
      and promote Th1 immunity. Although mammalian IL-18 has been characterized in 
      great detail, the properties and application of chicken IL-18 remain largely 
      uninvestigated as of yet. In this study, we evaluated the immunomodulatory 
      properties of Salmonella enterica serovar Typhimurium expressing chicken 
      interleukin-18 (chIL-18) on immune responses induced by avian influenza (AI) and 
      Newcastle disease (ND) vaccines. After oral administration of S. enterica serovar 
      Typhimurium expressing chIL-18, chickens were vaccinated intramuscularly with the 
      recommended dose of either inactivated AI H9N2 vaccine or ND (B1 strain) vaccine. 
      Chickens receiving a primary vaccination were boosted using the same protocol 7 
      days later. Humoral and cell-mediated immune responses were evaluated in terms of 
      HI antibody titers and proliferation and mRNA expression of IFN-gamma and IL-4 of 
      peripheral blood mononuclear cells (PBMC) in response to specific antigen 
      stimulation. According to our results, oral administration of S. enterica serovar 
      Typhimurium expressing chIL-18 induced enhanced humoral and Th1-biased 
      cell-mediated immunity against AI and ND vaccines, compared to that of chickens 
      received S. enterica serovar Typhimurium harboring empty vector. Therefore, we 
      conclude that our proposed vaccination regimen using inactivated AI and ND 
      viruses along with oral administration of S. enterica serovar Typhimurium 
      expressing chIL-18 may provide a novel approach in protecting chicken from 
      currently circulating AI and ND virus strains.
FAU - Rahman, Md Masudur
AU  - Rahman MM
AD  - College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk 
      National University, Jeonju 561-756, Korea.
FAU - Uyangaa, Erdenebileg
AU  - Uyangaa E
FAU - Eo, Seong Kug
AU  - Eo SK
LA  - eng
PT  - Journal Article
DEP - 20130228
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC3607709
OTO - NOTNLM
OT  - Avian influenza
OT  - Chicken interleukin-18
OT  - Immune modulation
OT  - Newcastle disease
OT  - Salmonella vaccine
COIS- The authors declare no financial or commercial conflict of interests.
EDAT- 2013/04/06 06:00
MHDA- 2013/04/06 06:01
PMCR- 2013/02/01
CRDT- 2013/04/06 06:00
PHST- 2013/01/22 00:00 [received]
PHST- 2013/02/04 00:00 [revised]
PHST- 2013/02/08 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2013/04/06 06:01 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.4110/in.2013.13.1.34 [doi]
PST - ppublish
SO  - Immune Netw. 2013 Feb;13(1):34-41. doi: 10.4110/in.2013.13.1.34. Epub 2013 Feb 
      28.