PMID- 23560031
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130408
LR  - 20220321
IS  - 1874-3641 (Print)
IS  - 1874-3641 (Electronic)
IS  - 1874-3641 (Linking)
VI  - 7
DP  - 2013
TI  - Correlation from undiluted vitreous cytokines of untreated central retinal vein 
      occlusion with spectral domain optical coherence tomography.
PG  - 11-7
LID - 10.2174/1874364101307010011 [doi]
AB  - PURPOSE: To correlate inflammatory and proangiogenic key cytokines from undiluted 
      vitreous of treatment-naive central retinal vein occlusion (CRVO) patients with 
      SD-OCT parameters. METHODS: Thirty-five patients (age 71.1 years, 24 phakic, 30 
      nonischemic) underwent intravitreal combination therapy, including a single-site 
      23-gauge core vitrectomy. Twenty-eight samples from patients with idiopathic, 
      non-uveitis floaterectomy served as controls. Interleukin 6 (IL-6), monocyte 
      chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor 
      (VEGF-A) levels were correlated with the visual acuity (logMar), category of CRVO 
      (ischemic or nonischemic) and morphologic parameters, such as central macular 
      thickness-CMT, thickness of neurosensory retina-TNeuro, extent of serous retinal 
      detachment-SRT and disintegrity of the IS/OS and others. RESULTS: The mean IL-6 
      was 64.7pg/ml (SD +/- 115.8), MCP-1 1015.7 ( +/- 970.1), and VEGF-A 278.4 ( +/- 512.8), 
      which was significantly higher than the control IL-6 6.2 +/- 3.4pg/ml (P=0.06), 
      MCP-1 253.2 +/- 73.5 (P<0.0000001) and VEGF-A 7.0 +/- 4.9 (P<0.0006). All cytokines 
      correlated highly with one another (correlation coefficient r=0.82 for IL-6 and 
      MCP-1; r=0.68 for Il-6 and VEGF-A; r=0.64 for MCP-1 and VEGF-A). IL-6 correlated 
      significantly with CMT, TRT, SRT, dIS/OS, and dELM. MCP-1 correlated 
      significantly with SRT, dIS/OS, and dELM. VEGF-A correlated not with changes in 
      SD-OCT, while it had a trend to be higher in the ischemic versus the nonischemic 
      CRVO group (P=0.09). CONCLUSIONS: The inflammatory cytokines were more often 
      correlated with morphologic changes assessed by SD-OCT, whereas VEGF-A did not 
      correlate with CRVO-associated changes in SD-OCT. VEGF inhibition alone may not 
      be sufficient in decreasing the inflammatory response in CRVO therapy.
FAU - Koss, Mj
AU  - Koss M
AD  - Department of Ophthalmology, Goethe University, Frankfurt am Main, Germany ; 
      Doheny Eye institute, Los Angeles, USA.
FAU - Pfister, M
AU  - Pfister M
FAU - Rothweiler, F
AU  - Rothweiler F
FAU - Rejdak, R
AU  - Rejdak R
FAU - Ribeiro, R
AU  - Ribeiro R
FAU - Cinatl, J
AU  - Cinatl J
FAU - Schubert, R
AU  - Schubert R
FAU - Kohnen, T
AU  - Kohnen T
FAU - Koch, Fh
AU  - Koch F
LA  - eng
PT  - Journal Article
DEP - 20130308
PL  - Netherlands
TA  - Open Ophthalmol J
JT  - The open ophthalmology journal
JID - 101480505
PMC - PMC3613771
OTO - NOTNLM
OT  - CBA
OT  - CRVO
OT  - IL-6
OT  - MCP-1
OT  - SD-OCT.
OT  - VEGF
OT  - Vitreous samples
EDAT- 2013/04/06 06:00
MHDA- 2013/04/06 06:01
PMCR- 2013/01/01
CRDT- 2013/04/06 06:00
PHST- 2012/12/19 00:00 [received]
PHST- 2013/01/15 00:00 [revised]
PHST- 2013/01/15 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2013/04/06 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - TOOPHTJ-7-11 [pii]
AID - 10.2174/1874364101307010011 [doi]
PST - ppublish
SO  - Open Ophthalmol J. 2013;7:11-7. doi: 10.2174/1874364101307010011. Epub 2013 Mar 
      8.