PMID- 23561634
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20151119
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 24
IP  - 6
DP  - 2013 Sep
TI  - Diarrhoea is not the only symptom that needs to be treated in patients with 
      microscopic colitis.
PG  - 573-8
LID - S0953-6205(13)00049-6 [pii]
LID - 10.1016/j.ejim.2013.02.006 [doi]
AB  - BACKGROUND: Many patients with microscopic colitis (MC) also suffer from symptoms 
      of irritable bowel syndrome (IBS), but the only treatment given is 
      corticosteroids for the diarrhoea. The aim of this study was to examine how 
      social factors, life style factors and drug treatment affect symptoms and 
      well-being in patients suffering from MC. METHODS: Women, over the age of 
      73years, with biopsy-verified MC, at any Departments of Gastroenterology, Skane, 
      between 2002 and 2010 were invited. The questionnaires Gastrointestinal Symptom 
      Rating Scale (GSRS) and Psychological General Well-being Index (PGWB) were sent 
      by mail, along with questions about social and life style factors, and medical 
      history. RESULTS: Of 240 invited, 158 patients (66%) were included (median age 
      63years, range 27-73years). Only 26% had never smoked. Smoking and concomitant 
      IBS were associated with both impaired gastrointestinal symptoms (OR=3.96, 95% 
      CI=1.47-10.66 and OR=4.40, 95% CI=2.09-9.26, respectively) and impaired 
      psychological well-being (OR=2.77, 95% CI=1.04-7.34 and OR=3.82, 95% 
      CI=1.83-7.99, respectively). Treatment with proton pump inhibitors (PPI) was 
      associated with increased gastrointestinal symptoms (OR=3.44, 95% CI=1.45-8.16). 
      Age, social factors, and corticosteroids had no effect on symptoms or well-being. 
      Smoking was the only risk factor associated with IBS (OR=2.68, 95% 
      CI=1.115-6.26). CONCLUSION: Smoking and IBS are associated with impaired 
      gastrointestinal symptoms and psychological well-being in MC patients. PPI is 
      associated with impaired gastrointestinal symptoms.
CI  - Copyright (c) 2013 European Federation of Internal Medicine. Published by Elsevier 
      B.V. All rights reserved.
FAU - Roth, Bodil
AU  - Roth B
AD  - Department of Clinical Sciences, Division of Gastroenterology, Skane University 
      Hospital, Malmo, Lund University, Lund, Sweden.
FAU - Bengtsson, Mariette
AU  - Bengtsson M
FAU - Ohlsson, Bodil
AU  - Ohlsson B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130403
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Abdominal Pain/drug therapy/etiology/psychology
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking
MH  - Colitis, Microscopic/complications/*drug therapy/psychology
MH  - Constipation/drug therapy/etiology/psychology
MH  - Diarrhea/*drug therapy/etiology/psychology
MH  - Dyspepsia/drug therapy/etiology/psychology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/etiology/psychology
MH  - Humans
MH  - Irritable Bowel Syndrome/*drug therapy/etiology/psychology
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Quality of Life
MH  - *Smoking
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Drug treatment
OT  - Gastrointestinal symptoms
OT  - Irritable bowel syndrome
OT  - Life style factors
OT  - Microscopic colitis
OT  - Psychological well-being
EDAT- 2013/04/09 06:00
MHDA- 2014/04/04 06:00
CRDT- 2013/04/09 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/01/21 00:00 [revised]
PHST- 2013/02/11 00:00 [accepted]
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S0953-6205(13)00049-6 [pii]
AID - 10.1016/j.ejim.2013.02.006 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2013 Sep;24(6):573-8. doi: 10.1016/j.ejim.2013.02.006. Epub 
      2013 Apr 3.