PMID- 23562193
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20130408
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Mar-Apr
TI  - Can patients with common variable immunodeficiency have allergic rhinitis?
PG  - 79-83
LID - 10.2500/ajra.2013.27.3855 [doi]
AB  - BACKGROUND: Rhinosinusitis is highly prevalent in patients with common variable 
      immunodeficiency (CVID), and probably allergic rhinitis (AR) may be masked by a 
      history of repeated respiratory infections. The diagnosis of AR is based on the 
      patient's symptoms and detection of specific immunoglobulin E (IgE) to 
      aeroallergens. This study was designed to identify rhinitis of probable allergic 
      cause in patients with CVID. METHODS: This study included 72 adult CVID patients. 
      The patients were divided into three groups according to their history: 
      suggestive of AR, nonallergic rhinitis, and without rhinitis. They were tested 
      for total and specific IgE (in vivo and in vitro). RESULTS: The patients' mean 
      age was 38.2 years. A history of chronic rhinitis was observed in 59 (81.9%) of 
      the cases, 31 of which (43%) had a history suggestive of AR. Patients with a 
      history of rhinitis (whether allergic or nonallergic) presented an earlier onset 
      of symptoms and diagnosis of CVID. Total IgE was undetectable in 86.1% of 
      patients. AR was confirmed by detection of specific IgE to aeroallergens in only 
      5.6% of the patients. CONCLUSION: In CVID patients, chronic rhinitis may be 
      allergic, because many have personal and family histories suggestive of atopy. 
      However, in this study, allergy was confirmed by specific IgE detection in only 
      5.6% of cases. CVID patients with a history suggestive of AR commonly present 
      negative results on traditional testing, so additional experiments may be 
      necessary. One suggestion for the investigation of AR in CVID patients would be 
      nasal provocation with the most prevalent allergens.
FAU - Agondi, Rosana C
AU  - Agondi RC
AD  - Division of Clinical Immunology and Allergy, University of Sao Paulo, Sao Paulo, 
      Brazil. ragondi@gmail.com
FAU - Barros, Myrthes T
AU  - Barros MT
FAU - Kokron, Cristina M
AU  - Kokron CM
FAU - Cohon, Andrea
AU  - Cohon A
FAU - Oliveira, Ana K B
AU  - Oliveira AK
FAU - Kalil, Jorge
AU  - Kalil J
FAU - Giavina-Bianchi, Pedro
AU  - Giavina-Bianchi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Allergens)
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Allergens/*immunology
MH  - Common Variable Immunodeficiency/complications/epidemiology/*immunology
MH  - Epitopes/immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Seasonal/complications/epidemiology/*immunology
MH  - Skin Tests
MH  - Young Adult
EDAT- 2013/04/09 06:00
MHDA- 2013/10/29 06:00
CRDT- 2013/04/09 06:00
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.2500/ajra.2013.27.3855 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2013 Mar-Apr;27(2):79-83. doi: 10.2500/ajra.2013.27.3855.