PMID- 23562393
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20161125
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 123
DP  - 2013 May
TI  - Circulating levels of persistent organic pollutants (POPs) are associated with 
      left ventricular systolic and diastolic dysfunction in the elderly.
PG  - 39-45
LID - S0013-9351(13)00045-5 [pii]
LID - 10.1016/j.envres.2013.02.007 [doi]
AB  - BACKGROUND AND OBJECTIVE: Major risk factors for congestive heart failure (CHF) 
      are myocardial infarction, hypertension, diabetes, atrial fibrillation, smoking, 
      left ventricular hypertrophy (LVH) and obesity. However, since these risk factors 
      only explain part of the risk of CHF, we investigated whether persistent organic 
      pollutants (POPs) might also play a role. METHODS: In the Prospective 
      Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, left 
      ventricular ejection fraction, (EF), E/A-ratio and isovolumic relaxation time 
      (IVRT), were determined by echocardiography and serum samples of 21 POPs were 
      analyzed in serum measured by high-resolution chromatography coupled to 
      high-resolution mass spectrometry (HRGC/HRMS) in 998 subjects all aged 70 years. 
      RESULTS: In this cross-sectional analysis, high levels of several of the 
      polychlorinated biphenyls (PCB congeners 99, 118, 105, 138, 153, and 180) and 
      octachlorodibenzo-p-dioxin (OCDD) were significantly related to a decreased EF. 
      Some POPs were also related to a decreased E/A-ratio (PCBs 206 and 209). All the 
      results were adjusted for gender, hypertension, diabetes, smoking, LVH and BMI, 
      and subjects with myocardial infarction or atrial fibrillation were excluded from 
      the analysis. CONCLUSIONS: Circulating levels of POPs were related to impairments 
      in both left ventricular systolic and diastolic function independently of major 
      congestive heart failure risk factors, suggesting a possible role of POPs in 
      heart failure.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Sjoberg Lind, Ylva
AU  - Sjoberg Lind Y
AD  - Department of Emergency Medicine, Linkoping University Hospital, Linkoping, 
      Sweden.
FAU - Lind, P Monica
AU  - Lind PM
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Lind, Lars
AU  - Lind L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130404
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diastole/drug effects
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Polychlorinated Biphenyls/*adverse effects/*blood
MH  - Systole/drug effects
MH  - Ventricular Dysfunction, Left/*blood/diagnostic imaging
MH  - Ventricular Function, Left/*drug effects
EDAT- 2013/04/09 06:00
MHDA- 2013/07/09 06:00
CRDT- 2013/04/09 06:00
PHST- 2012/11/01 00:00 [received]
PHST- 2013/02/28 00:00 [revised]
PHST- 2013/02/28 00:00 [accepted]
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - S0013-9351(13)00045-5 [pii]
AID - 10.1016/j.envres.2013.02.007 [doi]
PST - ppublish
SO  - Environ Res. 2013 May;123:39-45. doi: 10.1016/j.envres.2013.02.007. Epub 2013 Apr 
      4.