PMID- 23562928
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20140720
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 57
DP  - 2013 Jul
TI  - Anti-inflammatory activity of hexane extracts from bones and internal organs of 
      Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin D(2) 
      generation in mast cells and anaphylaxis in mice.
PG  - 307-13
LID - S0278-6915(13)00212-3 [pii]
LID - 10.1016/j.fct.2013.03.029 [doi]
AB  - The purpose of this study is to investigate the effects of n-hexane extracts from 
      bones and internal organs of Japanese eel, Anguilla japonica (HEE), on 
      cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2)(PGD(2)) generation in stem cell 
      factor (SCF), IL-10, plus LPS-induced mouse bone marrow-derived mast cells 
      (BMMCs) and on passive cutaneous anaphylaxis (PCA) in mice. HEE suppressed 
      SCF/IL-10/LPS-induced PGD(2) generation, and concomitantly reduced COX-2 protein 
      expression dose-dependently. To understand the mechanistic basis for the 
      inhibition of PGD(2) generation by HEE, we examined the effects of HEE on upstream 
      signaling pathways essential for COX-2 induction. HEE was found to inhibit the 
      translocation of nuclear factor-kappaB (NF-kappaB) p65 subunit to the nucleus and its 
      DNA-binding ability through the inhibition of TAK1, IKK and IkappaB phosphorylation. 
      Furthermore, HEE also attenuated mitogen-activated protein kinase (MAPK)-mediated 
      regulation of DNA binding of activator protein-1 (AP-1). Moreover, oral 
      administration of HEE inhibited anti-dinitrophenyl (DNP) IgE-induced PCA in a 
      dose dependent manner. Taken together, the present study provides new insights 
      into the anti-inflammatory activity of HEE, which could be a promising candidate 
      to be used for an inflammatory therapy.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Lu, Yue
AU  - Lu Y
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
FAU - Na, Min Kyun
AU  - Na MK
FAU - Suh, Seok-Jong
AU  - Suh SJ
FAU - Li, Xian
AU  - Li X
FAU - Kim, Geum Jin
AU  - Kim GJ
FAU - Chao, Guang Hsuan
AU  - Chao GH
FAU - Jeong, Yong-Tae
AU  - Jeong YT
FAU - Kim, Dong Soo
AU  - Kim DS
FAU - Chang, Young-Chae
AU  - Chang YC
FAU - Murakami, Makoto
AU  - Murakami M
FAU - Kang, Wonku
AU  - Kang W
FAU - Kim, Cheorl-Ho
AU  - Kim CH
FAU - Chang, Hyeun Wook
AU  - Chang HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130402
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Complex Mixtures)
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Hexanes)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factor AP-1)
RN  - 130068-27-8 (Interleukin-10)
RN  - 2DDG612ED8 (n-hexane)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP kinase kinase kinase 7)
RN  - RXY07S6CZ2 (Prostaglandin D2)
SB  - IM
EIN - Food Chem Toxicol. 2014 May;67:288
MH  - Anaphylaxis/*drug therapy
MH  - Anguilla/*metabolism
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Bone and Bones/chemistry
MH  - Complex Mixtures/chemistry/*pharmacology
MH  - Cyclooxygenase 2/*metabolism
MH  - Cyclooxygenase 2 Inhibitors/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hexanes
MH  - Interleukin-10/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - MAP Kinase Kinase Kinases/metabolism
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - NF-kappa B/metabolism
MH  - Prostaglandin D2/*metabolism
MH  - Transcription Factor AP-1/metabolism
EDAT- 2013/04/09 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/04/09 06:00
PHST- 2012/09/25 00:00 [received]
PHST- 2013/02/20 00:00 [revised]
PHST- 2013/03/21 00:00 [accepted]
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - S0278-6915(13)00212-3 [pii]
AID - 10.1016/j.fct.2013.03.029 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Jul;57:307-13. doi: 10.1016/j.fct.2013.03.029. Epub 2013 
      Apr 2.