PMID- 23563728
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20190907
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 60
IP  - 7
DP  - 2013
TI  - Association of endothelial nitric oxide synthase gene polymorphisms with type 2 
      diabetes mellitus: a meta-analysis.
PG  - 893-901
AB  - A meta-analysis was performed to assess the association of endothelial nitric 
      oxide synthase (NOS3) gene polymorphisms [4b4a VNTR and G894T (rs1799983)] with 
      type 2 diabetes mellitus (T2DM). A comprehensive search was conducted to identify 
      all eligible articles. Fixed or random effect pooled measure was selected based 
      on homogeneity test. Heterogeneity among studies was evaluated using the I2. 
      Meta-regression was used to explore potential sources of between-study 
      heterogeneity. Publication bias was estimated using Egger's linear regression 
      test. 19 articles involving 8,009 subjects for 4b4a VNTR and 19 articles 
      involving 8,600 subjects for G894T were included. After excluding articles that 
      deviated from Hardy-Weinberg equilibrium in controls and sensitivity analysis, 
      significant association was found between 4a and increased risk of T2DM 
      considering dominant model [OR (95% CI)=1.32 (1.17-1.48)], a vs. b [OR (95% 
      CI)=1.34 (1.21-1.48)], and aa vs. bb [OR (95% CI)=1.52 (1.05-2.22)]. The 894T 
      allele was also found associated with increased risk of T2DM considering dominant 
      model [OR (95% CI)=1.14 (1.03-1.26)], recessive model [OR (95%CI)=1.28 
      (1.06-1.54)], T vs. G [OR (95% CI)=1.18 (1.09-1.27)], and TT vs. GG [OR (95% 
      CI)=1.33 (1.09-1.62)]. The findings were consistent in Asian population. The 
      meta-analysis indicated that NOS3 gene 4b4a VNTR and G894T polymorphisms might be 
      associated with T2DM risk.
FAU - Jia, Zhaotong
AU  - Jia Z
AD  - Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao 
      University, Qingdao 266003, China. jiazt1963@163.com
FAU - Zhang, Xiaoqian
AU  - Zhang X
FAU - Kang, Shan
AU  - Kang S
FAU - Wu, Yili
AU  - Wu Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130407
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies/statistics & numerical data
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats/genetics
MH  - Nitric Oxide Synthase Type III/*genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
EDAT- 2013/04/09 06:00
MHDA- 2014/04/01 06:00
CRDT- 2013/04/09 06:00
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
AID - DN/JST.JSTAGE/endocrj/EJ12-0463 [pii]
AID - 10.1507/endocrj.ej12-0463 [doi]
PST - ppublish
SO  - Endocr J. 2013;60(7):893-901. doi: 10.1507/endocrj.ej12-0463. Epub 2013 Apr 7.