PMID- 23563931
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20220331
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 24
IP  - 8
DP  - 2013 Aug
TI  - Serum osteocalcin levels are inversely associated with abdominal aortic 
      calcification in men with type 2 diabetes mellitus.
PG  - 2223-30
LID - 10.1007/s00198-013-2289-6 [doi]
AB  - We found that serum osteocalcin (OC) and undercarboxylated OC (ucOC) levels were 
      negatively associated with abdominal aortic calcification in type 2 diabetes 
      mellitus (T2DM) men. This finding suggests that circulating OC and ucOC are not 
      only related to glucose or fat metabolism but also to arteriosclerosis. 
      INTRODUCTION: Recent studies revealed that serum osteocalcin levels were 
      associated with not only bone metabolism but also glucose and fat metabolism. 
      However, the relationship between serum OC levels and arteriosclerosis remains 
      controversial. We examined whether or not bone metabolic markers including OC are 
      associated with abdominal aortic calcification in patients with type 2 diabetes 
      mellitus. METHODS: We recruited 118 men and 100 postmenopausal women with T2DM. 
      We evaluated the abdominal aortic calcification score (ACS) on a lateral lumbar 
      radiograph and examined the association between serum OC or undercarboxylated OC 
      levels and ACS. RESULTS: The ACS of 3 and greater, which corresponded well to the 
      highest quartile, was significantly and negatively associated with serum OC and 
      ucOC levels in men by logistic regression analyses after adjusting for age, BMI, 
      serum levels of creatinine and LDL cholesterol, radial bone mineral density, 
      smoking, duration of DM, hemoglobin A1c, and the index of insulin resistance 
      [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.19-0.70, P < 0.005, and OR 
      0.28, 95 % CI 0.12-0.69, P < 0.01, per standard deviation increase in OC and 
      ucOC, respectively]. These observations were still significant after an 
      additional adjustment for other bone markers. In contrast, there were no 
      significant relationships with serum OC or ucOC levels and ACS in women. 
      CONCLUSIONS: These findings suggest that serum OC and ucOC levels are associated 
      with not only bone metabolism but also arteriosclerosis in men, but not in women 
      with type 2 diabetes mellitus.
FAU - Ogawa-Furuya, N
AU  - Ogawa-Furuya N
AD  - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 
      Enya-cho, Izumo, Shimane 693-8501, Japan. noriko.o@med.shimane-u.ac.jp
FAU - Yamaguchi, T
AU  - Yamaguchi T
FAU - Yamamoto, M
AU  - Yamamoto M
FAU - Kanazawa, I
AU  - Kanazawa I
FAU - Sugimoto, T
AU  - Sugimoto T
LA  - eng
PT  - Journal Article
DEP - 20130406
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Aged
MH  - Aorta, Abdominal
MH  - Aortic Diseases/*blood/etiology/physiopathology
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Bone Density/physiology
MH  - Bone and Bones/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/complications/physiopathology
MH  - Diabetic Angiopathies/*blood/physiopathology
MH  - Female
MH  - Humans
MH  - Lipid Metabolism/physiology
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/*blood
MH  - Risk Assessment/methods
MH  - Vascular Calcification/*blood/etiology/physiopathology
EDAT- 2013/04/09 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/04/09 06:00
PHST- 2012/08/06 00:00 [received]
PHST- 2013/01/07 00:00 [accepted]
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - 10.1007/s00198-013-2289-6 [doi]
PST - ppublish
SO  - Osteoporos Int. 2013 Aug;24(8):2223-30. doi: 10.1007/s00198-013-2289-6. Epub 2013 
      Apr 6.