PMID- 23565397
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130409
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 16
IP  - Suppl 2
DP  - 2012 Dec
TI  - Multiple endocrine neoplasia type 1.
PG  - S272-4
LID - 10.4103/2230-8210.104058 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of 
      parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may 
      also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, 
      collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to 
      mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid 
      protein, menin. Thus, the finding of MEN1 in a patient has important implications 
      for family members because first-degree relatives have a 50% risk of developing 
      the disease and can often be identified by MEN1 mutational analysis. Patients 
      with MEN1 have a decreased life-expectancy and the outcomes of current 
      treatments, which are generally similar to that for the respective tumors 
      occurring in non-MEN1 patients, are not as successful because of multiple tumors, 
      which may be larger, more aggressive, and resistant to treatment, and the 
      concurrence of metastases. The prognosis for MEN1 patients might be improved by 
      pre-symptomatic tumor detection and undertaking treatment specific for 
      MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should 
      be cared for by multi-disciplinary teams comprising relevant specialists with 
      experience in the diagnosis and treatment of patients with endocrine tumors.
FAU - Thakker, R V
AU  - Thakker RV
AD  - Nuffield Department of Medicine, Oxford Centre for Diabetes, Endocrinology and 
      Metabolism, University of Oxford, Headington, Oxford, OX3 7LJ, UK.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3603045
OTO - NOTNLM
OT  - MEN1
OT  - pancreatic islet cell tumour
OT  - parathyroid tumour
OT  - pituitary tumour
COIS- Conflict of Interest: None declared
EDAT- 2013/04/09 06:00
MHDA- 2013/04/09 06:01
PMCR- 2012/12/01
CRDT- 2013/04/09 06:00
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2013/04/09 06:01 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - IJEM-16-272 [pii]
AID - 10.4103/2230-8210.104058 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S272-4. doi: 
      10.4103/2230-8210.104058.