PMID- 23565483
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130409
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 16
IP  - Suppl 2
DP  - 2012 Dec
TI  - Sertoli cell only syndrome: Status of sertoli cell maturation and function.
PG  - S512-3
LID - 10.4103/2230-8210.104154 [doi]
AB  - BACKGROUND OF THE STUDY: Mature and functional Sertoli cells are essential for 
      the survival of germ cells in testes. In Sertoli cell only syndrome (SCOS), there 
      is no germ cells. Then, question arises whether absence of germ cells in SCOS 
      secondary to Sertoli cells immaturity or mal function. Sertoli cells maturational 
      and functional status is unclear in SCOS. This study investigated status of 
      maturation and function of Sertoli cells in patients with SCOS. MATERIALS AND 
      METHODS: The present study was comprised of 37 cases of SCOS and 50 normal 
      control males. Detailed clinical examination and investigation were carried out 
      as per pre-determined proforma. Semen analysis, hormonal analysis (FSH, LH, 
      testosterone, etc.), and fine needle aspiration cytology (FNAC) of testes 
      (bilateral) were performed. Fluorescence in situ hybridization (FISH) with XY 
      probes was carried out in addition to conventional chromosome analysis to find 
      out chromosomal abnormalities, in particular sex chromosome aneuploidy, including 
      mosaicism. Yq microdeletion status was also investigated. The anti-mullerian 
      hormone (AMH), inhibin B, and seminal lactate were estimated by ELISA methods. 
      RESULTS: The study did not find any case of high AMH. About 78% cases had low 
      inhibin B, and 60% had low AMH. FSH was high in about 78% cases. Low level of 
      lactate was found in 49% cases. There was one case of high level of inhibin B. 
      There were 6 (16.2%) cases of chromosomal abnormality (2 mosaic Klinefelter and 4 
      Klinefelter syndrome) and 4 (10.8%) cases of Yq microdeletion. CONCLUSION: We 
      conclude that Sertoli cell immaturity does not play any role in SCOS (no case of 
      high AMH). It seems, in majority cases, Sertoli cells are functionally- and/or 
      numerically-deficient (low inhibin B, AMH and lactate). However, in about 22% 
      cases, Sertoli cell function and/or number remains normal (normal inhibin B, 
      AMH). Inhibin B and FSH seems best predictor/marker of Sertoli cell function.
FAU - Jain, Manish
AU  - Jain M
AD  - Department of Reproductive Biology, All India Institute of Medical Sciences, New 
      Delhi, India.
FAU - Halder, Ashutosh
AU  - Halder A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3603131
OTO - NOTNLM
OT  - Sertoli cell only syndrome
OT  - anti-mullerian hormone
OT  - headings not required
OT  - sertoli cells
EDAT- 2013/04/09 06:00
MHDA- 2013/04/09 06:01
PMCR- 2012/12/01
CRDT- 2013/04/09 06:00
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2013/04/09 06:01 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - IJEM-16-512 [pii]
AID - 10.4103/2230-8210.104154 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S512-3. doi: 
      10.4103/2230-8210.104154.