PMID- 23565830
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20131014
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 19
IP  - 11
DP  - 2013 Nov
TI  - Incidence of invasive fungal disease after unmanipulated haploidentical stem cell 
      transplantation was significantly higher than that after HLA-matched sibling 
      transplantation.
PG  - 1029-34
LID - 10.1111/1469-0691.12120 [doi]
AB  - The aim of this study was to determine the incidence, clinical features and 
      outcome of invasive fungal disease (IFD) after either unmanipulated 
      haploidentical haematopoietic stem cell transplantation (HSCT) or human leukocyte 
      antigen (HLA)-matched sibling HSCT. This was a head-to-head comparative study 
      performed at a single centre. Patients were admitted between 2007 and 2010, and 
      IFD was evaluated according to the revised EORTC/MSG criteria, with only proven 
      and probable cases included. Of the 1042 consecutive patients enrolled, 390 
      received the HLA-matched HSCT and 652 received unmanipulated haploidentical HSCT. 
      A total of 61 (5.8%) patients had IFD, including 15 proven cases and 46 probable 
      cases. The incidence of IFD after unmanipulated haploidentical HSCT was 
      significantly higher than that after HLA-matched transplantation (7.1% vs. 3.3%, 
      respectively; p 0.007). IFD occurred later in patients receiving HLA-matched 
      transplantation compared with patients receiving unmanipulated haploidentical 
      HSCT (141.5 vs. 23 days, respectively; p 0.04). In multivariate analysis, acute 
      graft-versus-host disease (GVHD) grades III to IV (HR = 2.214, 95% CI, 
      1.139-4.304; p 0.019), extensive chronic GVHD (HR = 2.413, 95% CI, 1.377-4.228; 
      p 0.002) and haploidentical transplantation (HR = 2.648, 95% CI, 1.111-6.310; 
      p 0.028) were identified as significant risk factors associated with IFD. The 
      response to antifungal therapy and the IFD-attributable mortality were similar 
      between the two types of transplantation. In conclusion, patients who received 
      unmanipulated haploidentical HSCT had a higher risk of IFD than those patients 
      who received HLA-matched HSCT, but the prognosis of IFD was not associated with 
      the HLA type.
CI  - (c) 2012 The Authors Clinical Microbiology and Infection (c) 2012 European Society of 
      Clinical Microbiology and Infectious Diseases.
FAU - Sun, Y
AU  - Sun Y
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation for the 
      Treatment of Hematological Diseases, Beijing, China.
FAU - Xu, L
AU  - Xu L
FAU - Liu, D
AU  - Liu D
FAU - Zhang, X
AU  - Zhang X
FAU - Han, W
AU  - Han W
FAU - Wang, Y
AU  - Wang Y
FAU - Chen, H
AU  - Chen H
FAU - Chen, Y
AU  - Chen Y
FAU - Wang, F
AU  - Wang F
FAU - Wang, J
AU  - Wang J
FAU - Ji, Y
AU  - Ji Y
FAU - Tang, F
AU  - Tang F
FAU - Liu, K
AU  - Liu K
FAU - Huang, X-J
AU  - Huang XJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antifungal Agents/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/*complications
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Mycoses/*epidemiology/pathology
MH  - Survival Analysis
MH  - *Tissue Donors
MH  - Transplantation, Homologous/*adverse effects
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Aspergillus
OT  - graft-versus-host disease
OT  - haematopoietic stem cell transplantation
OT  - haploidentical
OT  - invasive fungal disease
EDAT- 2013/04/10 06:00
MHDA- 2014/05/07 06:00
CRDT- 2013/04/10 06:00
PHST- 2012/05/22 00:00 [received]
PHST- 2012/11/02 00:00 [revised]
PHST- 2012/11/25 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
AID - S1198-743X(14)63005-6 [pii]
AID - 10.1111/1469-0691.12120 [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2013 Nov;19(11):1029-34. doi: 10.1111/1469-0691.12120. 
      Epub 2013 Apr 8.