PMID- 23566096
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20130409
IS  - 1750-192X (Electronic)
IS  - 1750-192X (Linking)
VI  - 5
IP  - 2
DP  - 2013 Apr
TI  - Transcriptional and epigenetic networks in the development and maturation of 
      dendritic cells.
PG  - 195-204
LID - 10.2217/epi.13.14 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that provide a 
      critical link between the innate and adaptive immune responses. The genetic 
      program required for differentiation of DCs from their hematopoietic precursors 
      is controlled by both cytokines and transcription factors. The signals transduced 
      from cytokines recruit specific transcription factors, enabling the expression of 
      a distinct transcriptome that is required for specification of different DC 
      lineages. The establishment of a distinct transcriptome also depends on chromatin 
      modifications associated with critical cis elements of lineage-specific genes. In 
      this review, recent advances in the understanding of the transcriptional network 
      governing DC lineage specification are summarized, along with current views of 
      the dynamic DC epigenome.
FAU - Kim, Hyoung-Pyo
AU  - Kim HP
AD  - Department of Environmental Medical Biology, Institute of Tropical Medicine, & 
      Brain Korea 21 Project for Medical Science, Yonsei University College of 
      Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea. 
      kimhp@yuhs.ac
FAU - Lee, Yeon-Su
AU  - Lee YS
FAU - Park, Jong Hoon
AU  - Park JH
FAU - Kim, Young-Joon
AU  - Kim YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Epigenomics
JT  - Epigenomics
JID - 101519720
RN  - 0 (Chromatin)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adaptive Immunity/genetics
MH  - Cell Differentiation/*genetics
MH  - Cell Lineage
MH  - Chromatin/genetics/metabolism
MH  - Cytokines/genetics/metabolism
MH  - *Dendritic Cells/cytology/physiology
MH  - Epigenesis, Genetic/*genetics
MH  - Gene Regulatory Networks/*genetics
MH  - Humans
MH  - Immunity, Innate/genetics
MH  - Signal Transduction
EDAT- 2013/04/10 06:00
MHDA- 2013/09/24 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 10.2217/epi.13.14 [doi]
PST - ppublish
SO  - Epigenomics. 2013 Apr;5(2):195-204. doi: 10.2217/epi.13.14.