PMID- 23566284
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 10
DP  - 2013 Apr 8
TI  - Complete genome sequence of acute viral necrosis virus associated with massive 
      mortality outbreaks in the Chinese scallop, Chlamys farreri.
PG  - 110
LID - 10.1186/1743-422X-10-110 [doi]
AB  - BACKGROUND: Acute viral necrosis virus (AVNV) is the causative agent of a serious 
      disease resulting in high mortality in cultured Chinese scallops, Chlamys 
      farreri. We have sequenced and analyzed the complete genome of AVNV. RESULTS: The 
      AVNV genome is a linear, double-stranded DNA molecule of 210,993 bp with a 
      nucleotide composition of 38.5% G + C. A total of 123 open reading frames were 
      predicted to encode functional proteins, ranging from 41 to 1,878 amino acid 
      residues. The DNA sequence of AVNV is 97% identical to that of ostreid 
      herpesvirus 1 (OsHV-1), and the amino acid sequences of the encoded proteins of 
      these two viruses are 94-100% identical. The genomic organization of AVNV is 
      similar to that of OsHV-1, and consists of two unique regions (170.4 kb and 3.4 
      kb, respectively), each flanked by two inverted repeats (7.6 kb and 10.2 kb, 
      respectively), with a third unique region (1.5 kb) situated between the two 
      internal repeats. CONCLUSIONS: Our results indicate that AVNV is a variant of 
      OsHV-1. The AVNV genome sequence provides information useful for understanding 
      the evolution and divergence of OsHV-1 in marine molluscs.
FAU - Ren, Weicheng
AU  - Ren W
AD  - Maricultural Organism Disease Control and Pathogenic Molecular Biology 
      Laboratory, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery 
      Science, Qingdao, 266071, China.
FAU - Chen, Haixia
AU  - Chen H
FAU - Renault, Tristan
AU  - Renault T
FAU - Cai, Yuyong
AU  - Cai Y
FAU - Bai, Changming
AU  - Bai C
FAU - Wang, Chongming
AU  - Wang C
FAU - Huang, Jie
AU  - Huang J
LA  - eng
SI  - GENBANK/AY509253
SI  - GENBANK/GQ153938
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (DNA, Viral)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Composition
MH  - China
MH  - DNA/chemistry/genetics
MH  - DNA Viruses/*genetics/isolation & purification
MH  - DNA, Viral/*chemistry/*genetics
MH  - Gene Order
MH  - *Genome, Viral
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Pectinidae/*virology
MH  - Sequence Analysis, DNA
MH  - Sequence Homology
MH  - Synteny
PMC - PMC3623871
EDAT- 2013/04/10 06:00
MHDA- 2014/01/23 06:00
PMCR- 2013/04/08
CRDT- 2013/04/10 06:00
PHST- 2012/06/30 00:00 [received]
PHST- 2013/03/28 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
PHST- 2013/04/08 00:00 [pmc-release]
AID - 1743-422X-10-110 [pii]
AID - 10.1186/1743-422X-10-110 [doi]
PST - epublish
SO  - Virol J. 2013 Apr 8;10:110. doi: 10.1186/1743-422X-10-110.